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Literature summary extracted from

  • Tran, N.T.; Den Hengst, C.D.; Gomez-Escribano, J.P.; Buttner, M.J.
    Identification and characterization of CdgB, a diguanylate cyclase involved in developmental processes in Streptomyces coelicolor (2011), J. Bacteriol., 193, 3100-3108.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.65 Streptomyces coelicolor
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.65 GTP
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 Streptomyces coelicolor cyclic di-3',5'-guanylate + diphosphate
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.65 CdgB
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 Streptomyces coelicolor
2.7.7.65 cyclic dimeric GMP [c-di-GMP] B
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 Streptomyces coelicolor
2.7.7.65 diguanylate cyclase
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 Streptomyces coelicolor

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.65 37
-
 assay at Streptomyces coelicolor

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.65 8
-
 assay at Streptomyces coelicolor

General Information

EC Number General Information Comment Organism
2.7.7.65 malfunction heterologous expression of cdgB in Escherichia coli results in increased production of extracellular matrix in colonies and enhanced surface attachment of cells in standing liquid cultures. In Streptomyces coelicolor, both overexpression and deletion of cdgB inhibits aerial-mycelium formation, and overexpression also inhibits production of the antibiotic actinorhodin, implicating c-di-GMP in the regulation of developmental processes in Streptomyces Streptomyces coelicolor