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Literature summary extracted from

  • Mattheakis, L.C.; Sor, F.; Collier, R.J.
    Diphthamide synthesis in Saccharomyces cerevisiae: structure of the DPH2 gene (1993), Gene, 132, 149-154.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.108 expressed in Escherichia coli Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.108 59772
-
 x * 59772, calculated from amino acid sequence Saccharomyces cerevisiae
2.5.1.108 60000
-
 x * 60000, SDS-PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.108 L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine Saccharomyces cerevisiae
-
 2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine
-
 ?
2.5.1.108 L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine Saccharomyces cerevisiae FY251
-
 2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.108 Saccharomyces cerevisiae P32461
-
-
2.5.1.108 Saccharomyces cerevisiae FY251 P32461
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.108 L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine
-
 Saccharomyces cerevisiae 2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine
-
 ?
2.5.1.108 L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine
-
 Saccharomyces cerevisiae FY251 2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.108 ? x * 60000, SDS-PAGE Saccharomyces cerevisiae
2.5.1.108 ? x * 59772, calculated from amino acid sequence Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
2.5.1.108 diphthine synthase
-
 Saccharomyces cerevisiae
2.5.1.108 Dph2
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.108 S-adenosyl-L-methionine dependent on Saccharomyces cerevisiae