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Literature summary extracted from
- Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster (2010), Biochem. Biophys. Res. Commun., 401, 64-68.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.1.1.9 | nucleus | - |
Drosophila melanogaster | 5634 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.1.1.9 | ferricytochrome c + H2O | Drosophila melanogaster | - |
ferrocytochrome c + O2 + H+ | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.1.1.9 | Drosophila melanogaster | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.1.1.9 | muscle | thoracic flight muscle | Drosophila melanogaster | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.1.1.9 | ferricytochrome c + H2O | - |
Drosophila melanogaster | ferrocytochrome c + O2 + H+ | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 7.1.1.9 | homodimer | - |
Drosophila melanogaster |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.1.1.9 | CCO | - |
Drosophila melanogaster |
| 7.1.1.9 | cytochrome c oxidase | - |
Drosophila melanogaster |
| 7.1.1.9 | ferrocytochrome c:oxygen oxidoreductase | - |
Drosophila melanogaster |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.9 | heme | - |
Drosophila melanogaster | |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 7.1.1.9 | Drosophila melanogaster | enzyme activity declines progressively with age between 10 and 47 days by 33% | down |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 7.1.1.9 | physiological function | the enzyme is a specific intra-mitochondrial site of age-related deterioration, which has a broad impact on mitochondrial physiology. The decline in enzyme activity during aging is associated with selective losses in the levels of both nuclear and mitochondrial DNA-encoded enzyme subunits | Drosophila melanogaster |
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Release 2023.1 (January 2023)
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