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Literature summary extracted from

  • Mulichak, A.M.; Losey, H.C.; Lu, W.; Wawrzak, Z.; Walsh, C.T.; Garavito, R.M.
    Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway (2003), Proc. Natl. Acad. Sci. USA, 100, 9238-9243.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.311
-
 Amycolatopsis orientalis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.311 2.8 A crystal structures of GtfA complexes with vancomycin and the natural monoglycosylated peptide substrate devancoaminyl vancomycin Amycolatopsis orientalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.311 dTDP-beta-L-4-epi-vancosamine + devancosaminyl-vancomycin Amycolatopsis orientalis the enzyme is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin dTDP + chloroorienticin B
-
 ?
2.4.1.311 dTDP-beta-L-4-epi-vancosamine + devancosaminyl-vancomycin Amycolatopsis orientalis A82846 the enzyme is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin dTDP + chloroorienticin B
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.311 Amycolatopsis orientalis P96558
-
-
2.4.1.311 Amycolatopsis orientalis A82846 P96558
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.311
-
 Amycolatopsis orientalis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.311 dTDP-beta-L-4-epi-vancosamine + devancosaminyl-vancomycin the enzyme is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin Amycolatopsis orientalis dTDP + chloroorienticin B
-
 ?
2.4.1.311 dTDP-beta-L-4-epi-vancosamine + devancosaminyl-vancomycin the enzyme is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin Amycolatopsis orientalis A82846 dTDP + chloroorienticin B
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.311 GtfA
-
 Amycolatopsis orientalis

General Information

EC Number General Information Comment Organism
2.4.1.311 physiological function the enzyme is involved in the biosynthesis of chloroeremomycin Amycolatopsis orientalis