EC Number | Application | Comment | Organism |
---|---|---|---|
2.5.1.46 | drug development | fungal DHS is a target for the development of inhibitors, for which CNI-1493 may serve as a lead substance | Fusarium graminearum |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.5.1.46 | DHS gene, DNA and amino acid sequence determination and analysis | Triticum aestivum |
2.5.1.46 | DHS gene, DNA and amino acid sequence determination and analysis | Fusarium graminearum |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.46 | CNI-1493 | inhibition in vitro and in vivo, inhibits germination conidia. Although DHS of wheat, fungus, and human can be equally inhibited by the inhibitor CNI-1493 in vitro, application during infection of wheat and maize flowers results in strong inhibition of the pathogen without interference with kernel development, providing the possibiity to selectively inhibit fungal growth without affecting plant growth | Fusarium graminearum | |
2.5.1.46 | CNI-1493 | inhibition in vitro. Although DHS of wheat, fungus, and human can be equally inhibited by the inhibitor CNI-1493 in vitro, application during infection of wheat and maize flowers results in strong inhibition of the pathogen without interference with kernel development, providing the possibiity to selectively inhibit fungal growth without affecting plant growth | Triticum aestivum | |
2.5.1.46 | CNI-1493 | inhibition in vitro. Although DHS of wheat, fungus, and human can be equally inhibited by the inhibitor CNI-1493 in vitro, application during infection of wheat and maize flowers results in strong inhibition of the pathogen without interference with kernel development, providing the possibiity to selectively inhibit fungal growth without affecting plant growth | Zea mays |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.5.1.46 | 41400 | - |
x * 41400, about, sequence calculation | Triticum aestivum |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.46 | [eIF5A-precursor]-lysine + spermidine | Triticum aestivum | - |
[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
2.5.1.46 | [eIF5A-precursor]-lysine + spermidine | Zea mays | - |
[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
2.5.1.46 | [eIF5A-precursor]-lysine + spermidine | Fusarium graminearum | - |
[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
2.5.1.46 | [eIF5A-precursor]-lysine + spermidine | Fusarium graminearum FG00323.1 | - |
[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.46 | Fusarium graminearum | - |
- |
- |
2.5.1.46 | Fusarium graminearum FG00323.1 | - |
- |
- |
2.5.1.46 | Triticum aestivum | - |
- |
- |
2.5.1.46 | Zea mays | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.5.1.46 | leaf | - |
Triticum aestivum | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.46 | [eIF5A-precursor]-lysine + spermidine | - |
Triticum aestivum | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
2.5.1.46 | [eIF5A-precursor]-lysine + spermidine | - |
Zea mays | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
2.5.1.46 | [eIF5A-precursor]-lysine + spermidine | - |
Fusarium graminearum | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
2.5.1.46 | [eIF5A-precursor]-lysine + spermidine | - |
Fusarium graminearum FG00323.1 | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.5.1.46 | ? | x * 41400, about, sequence calculation | Triticum aestivum |