Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ezhilarasan, V.; Sharma, O.; Pan, A.
    In silico identification of potential drug targets in Clostridium difficile R20291: modeling and virtual screening analysis of a candidate enzyme MurG (2012), Med. Chem. Res., 22, 2692-2705.
No PubMed abstract available

Application

EC Number Application Comment Organism
2.4.1.227 drug development MurG is a target for drug development to treat diseases caused by Clostridium difficile, an etiologic agent of a variety of gastrointestinal diseases in humans including mild sporadic diarrhea and severe life-threatening pseudomembranous colitis Clostridioides difficile

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.227 (1R,3R,3aS,6aR)-1-{[2-({[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl] methyl}amino)-2-oxoethyl]carbamoyl}-3-(2-methoxyphenyl)-1-methyl-4,6-dioxo-5-phenyloctahydropyrrolo[3,4-c]pyrrol-2-ium
-
 Clostridioides difficile
2.4.1.227 (4R,4aR,5aS,6R,12aS)-4-(dimethylamino)-1,5,10,12,12a-pentahydroxy-6-methyl-3,11-dioxo-3,4,4a,5,5a,6,11,12a- octahydrotetracene-2-carboxamide
-
 Clostridioides difficile
2.4.1.227 ({2-[3-(4-methoxybenzyl)-6-(methoxycarbonyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-2-oxoethyl}sulfanyl)acetic acid
-
 Clostridioides difficile
2.4.1.227 2-(carboxyethynyl)-3,4-dihydroxybenzoic acid
-
 Clostridioides difficile
2.4.1.227 2-(phosphonooxy)butanoic acid
-
 Clostridioides difficile
2.4.1.227 4-{[(1S,11aS)-5,11-dioxo-7-phenyl-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-1-yl]amino}-4-oxobutanoic acid
-
 Clostridioides difficile
2.4.1.227 5'-deoxy-5'-[(N-{[(2R,3R,4R,5R)-3-(methoxycarbonyl)-5-(2-methoxyphenyl)-2,4-dimethylpyrrolidinium-2-yl]carbonyl}glycyl) amino]uridine
-
 Clostridioides difficile
2.4.1.227 additional information inhibitor binding mode, molecular modeling, overview Clostridioides difficile
2.4.1.227 N-({6-[(4-cyano-2-fluorobenzyl)oxy]naphthalen-2-yl}sulfonyl)-D-glutamic acid
-
 Clostridioides difficile
2.4.1.227 [1-hydroxy-2-(pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid)
-
 Clostridioides difficile

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.227 Clostridioides difficile
-
-
-
2.4.1.227 Clostridioides difficile R20291
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.227 additional information sMurG uses UDP-N-acetylglucosamine as substrate Clostridioides difficile ?
-
 ?
2.4.1.227 additional information sMurG uses UDP-N-acetylglucosamine as substrate Clostridioides difficile R20291 ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.227 More structure comparison with the enzyme from Escherichia coli, molecular modeling and structure validation, overview Clostridioides difficile

Synonyms

EC Number Synonyms Comment Organism
2.4.1.227 MurG
-
 Clostridioides difficile

General Information

EC Number General Information Comment Organism
2.4.1.227 additional information the active site residue Gln298 plays a critical role in ligand-target interactions, other active site residues like Arg168, Ser198, Arg202, Ser269, and His297 also play roles in binding interactions, docking study, and molecular modeling and structure validation, overview Clostridioides difficile