Literature summary extracted from

Almudi, I.; Corominas, M.; Serras, F.
Competition between SOCS36E and Drk modulates Sevenless receptor tyrosine kinase activity (2010), J. Cell Sci., 123, 3857-3862.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.10.1	Drosophila melanogaster	-	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.10.1	SEV	-	Drosophila melanogaster
2.7.10.1	sevenless receptor tyrosine kinase	-	Drosophila melanogaster

General Information

EC Number	General Information	Comment	Organism
2.7.10.1	physiological function	Sevenless receptor tyrosine kinase binds directly to either the suppressor of cytokine signalling SOCS36E or the adaptor protein Drk, i.e. downstream of receptor kinase. In a mechanistic model, the competition between these two proteins for binding to the same docking site results in either attenuation of the Sevenless receptor tyrosine kinase transduction in cells that should not develop R7 photoreceptors or amplification of the Ras-MAPK signal only in the R7 precursor	Drosophila melanogaster

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Release 2023.1 (January 2023)