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Literature summary extracted from

  • Nagata, E.; Saiardi, A.; Tsukamoto, H.; Okada, Y.; Itoh, Y.; Satoh, T.; Itoh, J.; Margolis, R.L.; Takizawa, S.; Sawa, A.; Takagi, S.
    Inositol hexakisphosphate kinases induce cell death in Huntington disease (2011), J. Biol. Chem., 286, 26680-26686.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.4.21 cytoplasm isoform InsP6K2 is localized mainly in the cytoplasm of lymphoblast cells from patients with Huntington disease Homo sapiens 5737
-
2.7.4.21 nucleus isoform InsP6K2 is localized mainly in the nucleus of normal lymphoblast cells Homo sapiens 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.4.21 50000
-
 x * 50000, isoform InsP6K2, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.21 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.21 HEK-293 cell
-
 Homo sapiens
-
2.7.4.21 lymphoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate
-
 Homo sapiens ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.4.21 ? x * 50000, isoform InsP6K2, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.4.21 inositol hexakisphosphate kinase type 2
-
 Homo sapiens
2.7.4.21 InsP6K2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.4.21 physiological function inositol hexakisphosphate kinase induces cell death in Huntington disease. The enzyme mediates apoptotic cell death via its translocation from the nucleus to the cytoplasm. Overexpression of the enzyme leads to the depletion of Akt phosphorylation and the induction of cell death Homo sapiens