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Literature summary extracted from

  • Harper, M.; Cox, A.D.; St Michael, F.; Ford, M.; Wilkie, I.W.; Adler, B.; Boyce, J.D.
    Natural selection in the chicken host identifies 3-deoxy-D-manno-octulosonic acid kinase residues essential for phosphorylation of Pasteurella multocida lipopolysaccharide (2010), Infect. Immun., 78, 3669-3677.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.166 A112V spontaneous KdkA mutant strain isolated from birds inoculated with high doses of a heptosyltransferase hptA mutant. The birds developed fowl cholera and the Pasteurella multocida isolates recovered from diseased birds no longer express truncated lipopolysaccharide. Mutation results in low level of enzymic acitivity Pasteurella multocida
2.7.1.166 D193N spontaneous KdkA mutant strain isolated from birds inoculated with high doses of a heptosyltransferase hptA mutant. The birds developed fowl cholera and the Pasteurella multocida isolates recovered from diseased birds no longer express truncated lipopolysaccharide. Mutation leads to complete loss of enzymic acitivity Pasteurella multocida
2.7.1.166 H168Y spontaneous KdkA mutant strain isolated from birds inoculated with high doses of a heptosyltransferase hptA mutant. The birds developed fowl cholera and the Pasteurella multocida isolates recovered from diseased birds no longer express truncated lipopolysaccharide. Residue is critical for Kdo kinase function and therefore glycoform A lipopolysaccharide assembly Pasteurella multocida
2.7.1.166 R123P spontaneous KdkA mutant strain isolated from birds inoculated with high doses of a heptosyltransferase hptA mutant. The birds developed fowl cholera and the Pasteurella multocida isolates recovered from diseased birds no longer express truncated lipopolysaccharide. Mutation is likely to have a significant impact on the secondary structure and probably affects the hinge action of the linker region Pasteurella multocida

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.166 Pasteurella multocida D9MNH9
-
-

Synonyms

EC Number Synonyms Comment Organism
2.7.1.166 KdkA
-
 Pasteurella multocida
2.7.1.166 Kdo kinase
-
 Pasteurella multocida