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Literature summary extracted from

  • Sass, J.O.; Fischer, K.; Wang, R.; Christensen, E.; Scholl-Buergi, S.; Chang, R.; Kapelari, K.; Walter, M.
    D-glyceric aciduria is caused by genetic deficiency of D-glycerate kinase (GLYCTK) (2010), Hum. Mutat., 31, 1280-1285.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.165 expressed in HEK-293 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.165 F483S the mutant shows loss of enzyme activity. The mutation leads to D-glyceric acidemia Homo sapiens
2.7.1.165 F493C the mutant shows loss of enzyme activity. The mutation leads to D-glyceric acidemia Homo sapiens
2.7.1.165 L510C the mutant shows loss of enzyme activity. The mutation leads to D-glyceric acidemia Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.165 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.165 blood plasma
-
 Homo sapiens
-
2.7.1.165 urine
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.165 ATP + D-glycerate
-
 Homo sapiens ADP + 2-phospho-D-glycerate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.165 D-glycerate kinase
-
 Homo sapiens
2.7.1.165 Glyctk
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.165 malfunction D-glyceric aciduria is caused by genetic deficiency of D-glycerate kinase Homo sapiens