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Literature summary extracted from

  • Takashima, S.; Matsumoto, T.; Tsujimoto, M.; Tsuji, S.
    Effects of amino acid substitutions in the sialylmotifs on molecular expression and enzymatic activities of alpha2,8-sialyltransferases ST8Sia-I and ST8Sia-VI (2013), Glycobiology, 23, 603-612.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.4.3.8 A281V the mutant of isoform ST8Sia-I shows 103.7% activity with ganglioside GM3 Mus musculus
2.4.3.8 A328V the mutant of isoform ST8Sia-VI shows 77.2% activity with bovine submaxillary mucin Mus musculus
2.4.3.8 C286A the mutant of isoform ST8Sia-I shows no activity with ganglioside GM3 Mus musculus
2.4.3.8 C335A the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin Mus musculus
2.4.3.8 E288N the mutant of isoform ST8Sia-I shows 66.5% activity with ganglioside GM3 Mus musculus
2.4.3.8 E333G the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin Mus musculus
2.4.3.8 F277M the mutant of isoform ST8Sia-I shows 81.1% activity with ganglioside GM3 Mus musculus
2.4.3.8 G284E the mutant of isoform ST8Sia-I shows no activity with ganglioside GM3 Mus musculus
2.4.3.8 I291L the mutant of isoform ST8Sia-I shows 95.3% activity with ganglioside GM3 Mus musculus
2.4.3.8 I327L the mutant of isoform ST8Sia-VI shows 90% activity with bovine submaxillary mucin Mus musculus
2.4.3.8 K339S the mutant of isoform ST8Sia-VI shows 34.6% activity with bovine submaxillary mucin Mus musculus
2.4.3.8 L278I the mutant of isoform ST8Sia-I shows 11.9% activity with ganglioside GM3 Mus musculus
2.4.3.8 L283V the mutant of isoform ST8Sia-I shows 45.4% activity with ganglioside GM3 Mus musculus
2.4.3.8 L340I the mutant of isoform ST8Sia-VI shows 18.6% activity with bovine submaxillary mucin Mus musculus
2.4.3.8 M326F the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin Mus musculus
2.4.3.8 N337E the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin Mus musculus
2.4.3.8 S273A the mutant of isoform ST8Sia-I shows no activity with ganglioside GM3 Mus musculus
2.4.3.8 S290K the mutant of isoform ST8Sia-I shows 72.4% activity with ganglioside GM3 Mus musculus
2.4.3.8 S322A the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin Mus musculus
2.4.3.8 V279A the mutant of isoform ST8Sia-I shows 85.6% activity with ganglioside GM3 Mus musculus
2.4.3.8 V330A the mutant of isoform ST8Sia-VI shows 92% activity with bovine submaxillary mucin Mus musculus
2.4.3.8 V332L the mutant of isoform ST8Sia-VI shows 69.8% activity with bovine submaxillary mucin Mus musculus
2.4.3.8 W295A the mutant of isoform ST8Sia-I shows 3.3% activity with ganglioside GM3 Mus musculus
2.4.3.8 W344A the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.8 Mus musculus Q64687
-
-
2.4.3.8 Mus musculus Q8K4T1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.8 COS-7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.8 CMP-N-acetylneuraminate + bovine submaxillary mucin substrate for isoform ST8Sia-VI, 100% activity Mus musculus CMP + ?
-
 ?
2.4.3.8 CMP-N-acetylneuraminate + ganglioside GM3 substrate for isoform ST8Sia-I, 100% activity Mus musculus CMP + ?
-
 ?
2.4.3.8 additional information isoform ST8Sia-I shows no activity with bovine submaxillary mucin Mus musculus ?
-
 ?
2.4.3.8 additional information isoform ST8Sia-VI shows no activity towards ganglioside GM3 Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.3.8 alpha2,8-sialyltransferase
-
 Mus musculus
2.4.3.8 ST8Sia-I isoform Mus musculus
2.4.3.8 ST8Sia-VI isoform Mus musculus

General Information

EC Number General Information Comment Organism
2.4.3.8 metabolism isoform ST8Sia-I is involved in the synthesis of ganglioside GD3 Mus musculus
2.4.3.8 metabolism isoform ST8Sia-VI isinvolved in the synthesis of disialic acid structures on O-glycans Mus musculus