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Literature summary extracted from

  • Ju, J.; Ozanick, S.G.; Shen, B.; Thomas, M.,G.
    Conversion of (2S)-arginine to (2S,3R)-capreomycidine by VioC and VioD from the viomycin biosynthetic pathway of Streptomyces sp. strain ATCC11861 (2004), Chembiochem, 5, 1281-1285.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.41 overexpression in Escherichia coli with an N-terminal hexahistidine affinity tag Streptomyces sp.
4.2.1.145 overproduced in Escherichia coli with an N-terminal hexahistidine affinity tag Streptomyces sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.145 (2S,3S)-3-hydroxyarginine Streptomyces sp.
-
 (2S,3R)-capreomycidine
-
 ?
4.2.1.145 (2S,3S)-3-hydroxyarginine Streptomyces sp. ATCC 11861
-
 (2S,3R)-capreomycidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.41 Streptomyces sp.
-
-
-
1.14.11.41 Streptomyces sp. ATCC 11861
-
-
-
4.2.1.145 Streptomyces sp.
-
-
-
4.2.1.145 Streptomyces sp. ATCC 11861
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.11.41
-
 Streptomyces sp.
4.2.1.145
-
 Streptomyces sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.41 L-arginine + 2-oxoglutarate + O2
-
 Streptomyces sp. (3S)-3-hydroxy-L-arginine + succinate + CO2
-
 ?
1.14.11.41 L-arginine + 2-oxoglutarate + O2
-
 Streptomyces sp. ATCC 11861 (3S)-3-hydroxy-L-arginine + succinate + CO2
-
 ?
4.2.1.145 (2S,3S)-3-hydroxyarginine
-
 Streptomyces sp. (2S,3R)-capreomycidine
-
 ?
4.2.1.145 (2S,3S)-3-hydroxyarginine
-
 Streptomyces sp. ATCC 11861 (2S,3R)-capreomycidine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.41 VioC
-
 Streptomyces sp.
4.2.1.145 VioD
-
 Streptomyces sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.11.41 7.5
-
 assay at Streptomyces sp.
4.2.1.145 7.5
-
 assay at Streptomyces sp.

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.145 pyridoxal 5'-phosphate
-
 Streptomyces sp.

General Information

EC Number General Information Comment Organism
1.14.11.41 physiological function the enzyme is involved in the biosynthesis of viomycin (an antibiotic of the tuberactinomycin family) Streptomyces sp.