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Literature summary extracted from

  • Ribeiro, A.L.; Degiacomi, G.; Ewann, F.; Buroni, S.; Incandela, M.L.; Chiarelli, L.R.; Mori, G.; Kim, J.; Contreras-Dominguez, M.; Park, Y.S.; Han, S.J.; Brodin, P.; Valentini, G.; Rizzi, M.; Riccardi, G.; Pasca, M.R.
    Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis (2011), PLoS ONE, 6, e26675.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.98.3 expression in Escherichia coli Mycolicibacterium smegmatis

Protein Variants

EC Number Protein Variants Comment Organism
1.1.98.3 additional information isolation of mutant strains resistant to dinitrobenzamides. All mutants show cross-resistance to benzothiazinones and dinitrobenzamides, and all the mutant strains with a higher level of resistance to dinitrobenzamides have a substitution C394G of MSMEG_6382 gene encoding decaprenylphospho-?-D-ribofuranose 2-oxidase Mycolicibacterium smegmatis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.98.3 additional information benzothiazinone and dinitrobenzamide inhibitors target decaprenylphospho-beta-D-ribofuranose 2-oxidase DprE1. Several mutants showing high levels of dinitrobenzamide resistance, exhibit a mutation in residue Cys394 of DprE1 Mycolicibacterium smegmatis

Organism

EC Number Organism UniProt Comment Textmining
1.1.98.3 Mycolicibacterium smegmatis A0R607
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Synonyms

EC Number Synonyms Comment Organism
1.1.98.3 DprE2
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 Mycolicibacterium smegmatis
1.1.98.3 MSMEG_6382
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 Mycolicibacterium smegmatis