EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.56 | ATP | - |
Rattus norvegicus | |
3.4.24.56 | bradykinin | - |
Rattus norvegicus | |
3.4.24.56 | dynorphin B-9 | - |
Rattus norvegicus | |
3.4.24.56 | Triphosphate | - |
Rattus norvegicus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.24.56 | additional information | mutant with a deleted putative dimer interface in the C-terminal region is created, which results in a monomeric variant. Monomeric IDE retains enzymatic activity. Monomeric IDE retains, 25% of the wild type activity substrate (Abz-GGFLRKHGQ-EDDnp). With the peptide substrates beta-endorphin and amyloid beta peptide 1-40, monomeric IDE retains 1 to 0.25% of wild type activity. No activation through bradykinin or dynorphin B-9. Monomeric IDE is not activated by polyphosphates | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.24.56 | 0.0066 | - |
Abz-GGFLRKHGQ-EDDnp | pH 7.4, temperature not specified in the publication, mutant DELTAC lacking the C-terminal region | Rattus norvegicus | |
3.4.24.56 | 0.0215 | - |
Abz-GGFLRKHGQ-EDDnp | pH 7.4, temperature not specified in the publication, wild-type | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.56 | Rattus norvegicus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.56 | Abz-GGFLRKHGQ-EDDnp + H2O | - |
Rattus norvegicus | Abz-GGFLR + KHGQ-EDDnp | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.24.56 | dimer | - |
Rattus norvegicus |
3.4.24.56 | monomer | mutant with a deleted putative dimer interface in the C-terminal region is created, which results in a monomeric variant. Monomeric IDE retains 25% of the wild type activity substrate (Abz-GGFLRKHGQ-EDDnp). With the peptide substrates beta-endorphin and amyloid beta peptide, monomeric IDE retains 1 to 0.25% of wild type activity. No activation through bradykinin or dynorphin B-9. Monomeric IDE is not activated by polyphosphates | Rattus norvegicus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.56 | IDE | - |
Rattus norvegicus |
3.4.24.56 | Insulysin | - |
Rattus norvegicus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.24.56 | 0.01 | - |
Abz-GGFLRKHGQ-EDDnp | pH 7.4, temperature not specified in the publication, mutant DELTAC lacking the C-terminal region | Rattus norvegicus | |
3.4.24.56 | 0.043 | - |
Abz-GGFLRKHGQ-EDDnp | pH 7.4, temperature not specified in the publication, wild-type | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.24.56 | 7.4 | - |
assay at | Rattus norvegicus |