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Literature summary extracted from

  • Cherian, P.T.; Yao, J.; Leonardi, R.; Maddox, M.M.; Luna, V.A.; Rock, C.O.; Lee, R.E.
    Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria (2012), Bioorg. Med. Chem., 20, 4985-4994.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.275 4-methoxyphenyl palmitoylsulfamate good antimicrobial activity against both Staphylococcus aureus and Bacillus anthracis Bacillus anthracis
2.3.1.275 4-methoxyphenyl palmitoylsulfamate good antimicrobial activity against both Staphylococcus aureus and Bacillus anthracis Staphylococcus aureus
2.3.1.275 4-methoxyphenyl undec-10-enoylsulfamate broad antimicrobial profile with good activity against multiple species of Gram-positive bacteria Bacillus anthracis
2.3.1.275 4-methoxyphenyl undec-10-enoylsulfamate broad antimicrobial profile with good activity against multiple species of Gram-positive bacteria Staphylococcus aureus
2.3.1.275 additional information data suggest that acylsulfamate inhibitors may have off-target effects on bacterial membrane function Bacillus anthracis
2.3.1.275 phenyl (8-phenyloctanoyl)sulfamate good antimicrobial activity against both Staphylococcus aureus and Bacillus anthracis. Compound causes an abrupt cessation of cell growth and inhibits inhibits protein, DNA and RNA synthesis in Bacillus anthracis Sterne Bacillus anthracis
2.3.1.275 phenyl (8-phenyloctanoyl)sulfamate good antimicrobial activity against both Staphylococcus aureus and Bacillus anthracis. Staphylococcus aureus cell growth does not immediately cease following addition, but slows down over approximately 2 h before stopping completely. Compound causes a concentration dependent decrease in acetate incorporation into fatty acids and membrane phospholipids Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.275 Bacillus anthracis
-
-
-
2.3.1.275 Staphylococcus aureus
-
-
-

Synonyms

EC Number Synonyms Comment Organism
2.3.1.275 PlsY
-
 Staphylococcus aureus
2.3.1.275 PlsY1
-
 Bacillus anthracis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.275 0.008
-
 pH 7.4, 37°C Staphylococcus aureus 4-methoxyphenyl palmitoylsulfamate
2.3.1.275 0.025
-
 pH 7.4, 37°C Staphylococcus aureus phenyl (8-phenyloctanoyl)sulfamate
2.3.1.275 0.027
-
 pH 7.4, 37°C Staphylococcus aureus 4-methoxyphenyl undec-10-enoylsulfamate