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Literature summary extracted from

  • Lee, S.B.; Park, J.H.; Folk, J.E.; Deck, J.A.; Pegg, A.E.; Sokabe, M.; Fraser, C.S.; Park, M.H.
    Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1) (2011), Biochem. J., 433, 205-213.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.57
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.57 additional information synthetic peptide IVEMSTSKTGK50HGHAK modeled on the sequence of amino acids surrounding the hypusine residue K50, 50% inhibition of eIF5A acetylation at 0.05 mM Homo sapiens
2.3.1.57 spermidine 0.005 mM, strong inhibition of eIF5A acetylation Homo sapiens
2.3.1.57 spermine 0.05 mM, strong inhibition of eIF5A acetylation Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.57 acetyl-CoA + eIF5A Homo sapiens
-
 CoA + acytyl-eIF5A selective acetylation of the hypusine and/or deoxyhypusine residue of translation initiation factor eIF5A, resulting in loss of eIF5A activity. Hypusine or deoxyhypusine, as the free amino acid, do not act as a substrate for isoform SSAT1 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.57 Homo sapiens P21673
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.57 acetyl-CoA + eIF5A
-
 Homo sapiens CoA + acytyl-eIF5A selective acetylation of the hypusine and/or deoxyhypusine residue of translation initiation factor eIF5A, resulting in loss of eIF5A activity. Hypusine or deoxyhypusine, as the free amino acid, do not act as a substrate for isoform SSAT1 ?