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Literature summary extracted from
- Diverse biological activities of the vascular non-inflammatory molecules - the Vanin pantetheinases (2012), Biochem. Biophys. Res. Commun., 417, 653-658.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.5.1.92 | membrane | - |
Mus musculus | 16020 | - |
| 3.5.1.92 | membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.92 | 6-O-[N-acetyl-alpha-D-glucosaminyl]-1-octadecylphospho-1D-myo-inositol + H2O | Homo sapiens | - |
6-O-alpha-D-glucosaminyl-1-octadecylphospho-1D-myo-inositol + acetate | - |
? |  |
| 3.5.1.92 | 6-O-[N-acetyl-alpha-D-glucosaminyl]-1-[1,2-bis(hexadecanoyl)-sn-glycero]phospho-1D-myo-inositol + H2O | Homo sapiens | - |
6-O-alpha-D-glucosaminyl-1-[1,2-bis(hexadecanoyl)-sn-glycero]phospho-1D-myo-inositol + acetate | - |
? | |
| 3.5.1.92 | pantetheine + H2O | Mus musculus | - |
pantothenate + cysteamine | - |
? | |
| 3.5.1.92 | pantetheine + H2O | Homo sapiens | - |
pantothenate + cysteamine | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.92 | Homo sapiens | - |
- |
- |
| 3.5.1.92 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.1.92 | intestine | - |
Mus musculus | - |
| 3.5.1.92 | intestine | - |
Homo sapiens | - |
| 3.5.1.92 | kidney | - |
Homo sapiens | - |
| 3.5.1.92 | leukocyte | peripheral blood leukocyte | Homo sapiens | - |
| 3.5.1.92 | liver | - |
Mus musculus | - |
| 3.5.1.92 | liver | - |
Homo sapiens | - |
| 3.5.1.92 | lymph node | - |
Homo sapiens | - |
| 3.5.1.92 | renal epithelium | - |
Mus musculus | - |
| 3.5.1.92 | respiratory system | - |
Homo sapiens | - |
| 3.5.1.92 | spleen | - |
Homo sapiens | - |
| 3.5.1.92 | thymus | - |
Homo sapiens | - |
| 3.5.1.92 | urethra | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.92 | 6-O-[N-acetyl-alpha-D-glucosaminyl]-1-octadecylphospho-1D-myo-inositol + H2O | - |
Homo sapiens | 6-O-alpha-D-glucosaminyl-1-octadecylphospho-1D-myo-inositol + acetate | - |
? | |
| 3.5.1.92 | 6-O-[N-acetyl-alpha-D-glucosaminyl]-1-[1,2-bis(hexadecanoyl)-sn-glycero]phospho-1D-myo-inositol + H2O | - |
Homo sapiens | 6-O-alpha-D-glucosaminyl-1-[1,2-bis(hexadecanoyl)-sn-glycero]phospho-1D-myo-inositol + acetate | - |
? | |
| 3.5.1.92 | pantetheine + H2O | - |
Mus musculus | pantothenate + cysteamine | - |
? | |
| 3.5.1.92 | pantetheine + H2O | - |
Homo sapiens | pantothenate + cysteamine | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.1.92 | pantetheinase | - |
Mus musculus |
| 3.5.1.92 | pantetheinase | - |
Homo sapiens |
| 3.5.1.92 | vanin 1 | - |
Mus musculus |
| 3.5.1.92 | vanin 1 | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.5.1.92 | malfunction | vanin 1 knockout mice display an enhanced resistance to oxidative stress and show down-regulated tissue inflammation in response to oxidative stress. Vanin knockout mice exhibit a loss of cysteamine-mediated inhibition of peroxisome proliferator-activated receptor gamma. Vanin 1 deficient islets are twice as susceptible to cell death as wild type cells | Mus musculus |
| 3.5.1.92 | physiological function | vanin plays a role in inflammation, oxidative stress, cell migration and numerous diseases including cardiovascular disease (increased vanin 1 activity has a protective effect against cardiovascular disease). Vanin 1 has a cytoprotective effect against type 1 diabetes in islet cells. Vanin 1 is a central regulator of not only stress responses via production of cysteamine but also lipid biosynthesis by controlling the flux through the fatty acid and/or cholesterol biosynthetic pathways | Mus musculus |
| 3.5.1.92 | physiological function | vanin plays a role in inflammation, oxidative stress, cell migration and numerous diseases including cardiovascular disease (increased vanin 1 activity has a protective effect against cardiovascular disease). Vanin 1 has a cytoprotective effect against type 1 diabetes in islet cells. Vanin 1 is a central regulator of not only stress responses via production of cysteamine but also lipid biosynthesis by controlling the flux through the fatty acid and/or cholesterol biosynthetic pathways | Homo sapiens |
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Release 2023.1 (January 2023)
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