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Literature summary extracted from

  • Van Der Geize, R.; Yam, K.; Heuser, T.; Wilbrink, M.; Hara, H.; Anderton, M.; Sim, E.; Dijkhuizen, L.; Davies, J.; Mohn, W.; Eltis, L.
    A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages (2007), Proc. Natl. Acad. Sci. USA, 104, 1947-1952.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.7.1.17 expressed in Escherichia coli strain GJ1158 Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.7.1.17 0.019
-
 2-hydroxy-6-oxo-6-phenyl-2,4-hexadienoic acid in 20 mM HEPES, 80 mM NaCl, at pH 8.0 and 25°C Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
3.7.1.17 Mycobacterium tuberculosis
-
-
-
3.7.1.17 Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.7.1.17 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O
-
 Mycobacterium tuberculosis ?
-
 ?
3.7.1.17 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O
-
 Mycobacterium tuberculosis H37Rv ?
-
 ?
3.7.1.17 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid + H2O the apparent specificity for 4,5–9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid is 34fold higher than for 2-hydroxy-6-oxo-6-phenylpentadienoate Mycobacterium tuberculosis 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid + ?
-
 ?
3.7.1.17 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid + H2O the apparent specificity for 4,5–9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid is 34fold higher than for 2-hydroxy-6-oxo-6-phenylpentadienoate Mycobacterium tuberculosis H37Rv 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.7.1.17 HsaD
-
 Mycobacterium tuberculosis