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Literature summary extracted from

  • Yu, Z.; Vodanovic-Jankovic, S.; Ledeboer, N.; Huang, S.X.; Rajski, S.R.; Kron, M.; Shen, B.
    Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase (2011), Org. Lett., 13, 2034-2037.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
6.3.5.6 biotechnology inhibitor represents a lead scaffold to discover and develop antifilarial drugs Brugia malayi

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.22 tirandamycin A selective inhibitor Brugia malayi
6.1.1.22 tirandamycin B selective inhibitor Brugia malayi
6.1.1.22 tirandamycin E selective inhibitor Brugia malayi
6.1.1.22 tirandamycin F selective inhibitor Brugia malayi
6.1.1.22 tirandamycin G selective inhibitor Brugia malayi
6.3.5.6 (3Z)-3-[(2E,4E)-1-hydroxy-6-[(2S,4R)-2-(hydroxymethyl)-1,7-dimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]dec-8-yl]-4-methylhepta-2,4-dien-1-ylidene]pyrrolidine-2,4-dione
-
 Brugia malayi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.22 ATP + L-asparagine + tRNAAsn Brugia malayi
-
 AMP + diphosphate + L-asparaginyl-tRNAAsn
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.22 Brugia malayi
-
-
-
6.3.5.6 Brugia malayi
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.22 ATP + L-asparagine + tRNAAsn
-
 Brugia malayi AMP + diphosphate + L-asparaginyl-tRNAAsn
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.22 AsnRS
-
 Brugia malayi
6.1.1.22 asparagine tRNA synthetase
-
 Brugia malayi
6.1.1.22 Asparaginyl-tRNA synthetase
-
 Brugia malayi
6.3.5.6 AsnRS
-
 Brugia malayi
6.3.5.6 Asparaginyl-tRNA synthetase
-
 Brugia malayi

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.22 ATP
-
 Brugia malayi

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.1.1.22 0.03
-
 pH and temperature not specified in the publication Brugia malayi tirandamycin G
6.3.5.6 0.03
-
 pH and temperature not specified in the publication, selectively inhibits the Brugia malayi AsnRS and efficiently kills the adult Brugia malayi parasite Brugia malayi (3Z)-3-[(2E,4E)-1-hydroxy-6-[(2S,4R)-2-(hydroxymethyl)-1,7-dimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]dec-8-yl]-4-methylhepta-2,4-dien-1-ylidene]pyrrolidine-2,4-dione