EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.22 | S-adenosyl-L-methionine | an allosteric activator | Homo sapiens |
EC Number | Application | Comment | Organism |
---|---|---|---|
4.2.1.22 | diagnostics | evaluation of plasma cystathionine beta-synthase activity in cystathionine beta-synthase-deficient patients for utilization of the assay in diagnosis and study of cystathionine beta-synthase deficiency | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
4.2.1.22 | cytosol | - |
Homo sapiens | 5829 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.22 | L-serine + L-homocysteine | Homo sapiens | - |
L-cystathionine + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.1.22 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.2.1.22 | kidney | - |
Homo sapiens | - |
4.2.1.22 | liver | - |
Homo sapiens | - |
4.2.1.22 | muscle | - |
Homo sapiens | - |
4.2.1.22 | pancreas | - |
Homo sapiens | - |
4.2.1.22 | plasma | cystathionine beta-synthase activities in wild-type individuals, and in hetero-, and homozygote cystathionine beta-synthase mutants, overview | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.22 | L-serine + L-homocysteine | - |
Homo sapiens | L-cystathionine + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.2.1.22 | CBS | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.22 | pyridoxal 5'-phosphate | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
4.2.1.22 | malfunction | cystathionine beta-synthase deficiency is a well-known genetic disease affecting the first step in the conversion of homocysteine to cysteine and ultimately to inorganic sulfur. The disease occurs in a mild and a severe form, phenotypes, overview. Cystathionine beta-synthase activities in wild-type individuals, and in hetero-, and homozygote cystathionine beta-synthase mutants, overview | Homo sapiens |