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Literature summary extracted from

  • Vlasits, J.; Jakopitsch, C.; Schwanninger, M.; Holubar, P.; Obinger, C.
    Hydrogen peroxide oxidation by catalase-peroxidase follows a non-scrambling mechanism (2007), FEBS Lett., 581, 320-324.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.11.1.21 D152S mutant with very low catalase activity Synechocystis sp.
1.11.1.21 H123E mutant with very low catalase activity Synechocystis sp.
1.11.1.21 R439A mutant with very low catalase activity Synechocystis sp.
1.11.1.21 W122F mutant without catalase activity Synechocystis sp.
1.11.1.21 Y249F mutant with very low catalase activity Synechocystis sp.

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.21 Mycobacterium tuberculosis
-
-
-
1.11.1.21 Synechocystis sp.
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.21 H2O2
-
 Mycobacterium tuberculosis O2 + H2O
-
 ?
1.11.1.21 H2O2
-
 Synechocystis sp. O2 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.21 KatG
-
 Mycobacterium tuberculosis
1.11.1.21 KatG
-
 Synechocystis sp.

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.11.1.21 2
-
 H2O2 catalase activity, mutant enzyme H123E, in 100 mM phosphate buffer, pH 7.0, at 23°C Synechocystis sp.
1.11.1.21 6
-
 H2O2 catalase activity, mutant enzyme Y249F, in 100 mM phosphate buffer, pH 7.0, at 23°C Synechocystis sp.
1.11.1.21 170
-
 H2O2 catalase activity, mutant enzyme R439A, in 100 mM phosphate buffer, pH 7.0, at 23°C Synechocystis sp.
1.11.1.21 200
-
 H2O2 catalase activity, mutant enzyme D152S, in 100 mM phosphate buffer, pH 7.0, at 23°C Synechocystis sp.
1.11.1.21 3500
-
 H2O2 catalase activity, wild type enzyme, in 100 mM phosphate buffer, pH 7.0, at 23°C Synechocystis sp.
1.11.1.21 6000
-
 H2O2 catalase activity, wild type enzyme, in 100 mM phosphate buffer, pH 7.0, at 23°C Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.1.21 heme
-
 Mycobacterium tuberculosis
1.11.1.21 heme
-
 Synechocystis sp.