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Literature summary extracted from

  • Yang, Y.; Gao, P.; Liu, Y.; Ji, X.; Gan, M.; Guan, Y.; Hao, X.; Li, Z.; Xiao, C.
    A discovery of novel Mycobacterium tuberculosis pantothenate synthetase inhibitors based on the molecular mechanism of actinomycin D inhibition (2011), Bioorg. Med. Chem. Lett., 21, 3943-3946.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.1 4-(2-{3-[(1E,3E)-hexa-1,3,5-trien-1-yl]phenyl}hydrazinyl)-4-oxobutanoic acid 27% inhibition Mycobacterium tuberculosis
6.3.2.1 actinomycin D
-
 Mycobacterium tuberculosis
6.3.2.1 methyl 6-amino-4-(benzyloxy)-1H-indole-2-carboxylate 69% inhibition Mycobacterium tuberculosis
6.3.2.1 nafronyl oxalate
-
 Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.1 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.1 ATP + (R)-pantoate + beta-alanine
-
 Mycobacterium tuberculosis AMP + diphosphate + (R)-pantothenate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.1 PanC
-
 Mycobacterium tuberculosis
6.3.2.1 Pantothenate synthetase
-
 Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.3.2.1 0.02244
-
 pH and temperature not specified in the publication Mycobacterium tuberculosis methyl 6-amino-4-(benzyloxy)-1H-indole-2-carboxylate
6.3.2.1 0.2507
-
 pH and temperature not specified in the publication Mycobacterium tuberculosis actinomycin D
6.3.2.1 0.3984
-
 pH and temperature not specified in the publication Mycobacterium tuberculosis nafronyl oxalate