Literature summary extracted from
Nagy, J.; Jesmin, J.; Servos, S.; Cass, A.; Brown, K.
Site-directed mutants of the catalase-peroxidase from Mycobacterium tuberculosis (1998), Biochem. Soc. Trans., 26, S281.
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
1.11.1.21 |
mutant enzymes are expressed in Escherichia coli strain UM255, lacking endogenous catalase |
Mycobacterium tuberculosis |
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
1.11.1.21 |
H108E |
isoniazid-resistant clinical mutant |
Mycobacterium tuberculosis |
1.11.1.21 |
H108L |
the mutant has lost both peroxidatic and catalatic activities |
Mycobacterium tuberculosis |
1.11.1.21 |
H52L |
isoniazid-resistant clinical mutant |
Mycobacterium tuberculosis |
1.11.1.21 |
R463L |
isoniazid-resistant clinical mutant, which has retained peroxidatic and catalatic activities |
Mycobacterium tuberculosis |
Molecular Weight [Da]
EC Number |
Molecular Weight [Da] |
Molecular Weight Maximum [Da] |
Comment |
Organism |
---|
1.11.1.21 |
80000 |
- |
x * 80000, SDS-PAGE |
Mycobacterium tuberculosis |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.11.1.21 |
Mycobacterium tuberculosis |
- |
- |
- |
Subunits
EC Number |
Subunits |
Comment |
Organism |
---|
1.11.1.21 |
? |
x * 80000, SDS-PAGE |
Mycobacterium tuberculosis |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
1.11.1.21 |
KatG |
- |
Mycobacterium tuberculosis |
Cofactor
EC Number |
Cofactor |
Comment |
Organism |
Structure |
---|
1.11.1.21 |
heme |
- |
Mycobacterium tuberculosis |
|
General Information
EC Number |
General Information |
Comment |
Organism |
---|
1.11.1.21 |
malfunction |
Mycobacterium tuberculosis isolates with defects in the kutG gene encoding a catalase-peroxidase enzyme exhibit resistance to isoniazid |
Mycobacterium tuberculosis |