BRENDA - Enzyme Database

Oxidosqualene cyclase residues that promote formation of cycloartenol, lanosterol, and parkeol

Khenkin, A.; Neumann, R.; Angew. Chem. 39, 4090-4092 (2000)
No PubMed abstract available

Data extracted from this reference:

Organism
EC Number
Organism
UniProt
Commentary
Textmining
5.4.99.47
Saccharomyces cerevisiae
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
5.4.99.47
(S)-2,3-oxidosqualene
-
713760
Saccharomyces cerevisiae
parkeol + lanosterol + lanost-24-ene-3beta,9alpha-diol
lanosterol-synthase mutant T384Y produces 11% parkeol, 79% lanosterol and 10% lanost-24-ene-3beta,9alpha-diol from (S)-2,3-oxidosqualene
-
-
?
5.4.99.47
(S)-2,3-oxidosqualene
-
713760
Saccharomyces cerevisiae
parkeol + lanosterol + lanost-24-ene-3beta,9alpha-diol
lanosterol-synthase mutant T384Y/V4545L produces 60% parkeol, 20% lanosterol and 20% lanost-24-ene-3beta,9alpha-diol from (S)-2,3-oxidosqualene
-
-
?
5.4.99.47
(S)-2,3-oxidosqualene
-
713760
Saccharomyces cerevisiae
parkeol + lanosterol + lanost-24-ene-3beta,9alpha-diol
lanosterol-synthase mutant T384Y/V454I produces 64% parkeol, 13% lanosterol and 23% lanost-24-ene-3beta,9alpha-diol from (S)-2,3-oxidosqualene
-
-
?
Synonyms
EC Number
Synonyms
Commentary
Organism
5.4.99.47
lanosterol-synthase mutant T384Y
cf. EC 5.4.99.7
Saccharomyces cerevisiae
5.4.99.47
lanosterol-synthase mutant T384Y/V454I
cf. EC 5.4.99.7
Saccharomyces cerevisiae
5.4.99.47
lanosterol-synthase mutant T384Y/V454L
cf. EC 5.4.99.7
Saccharomyces cerevisiae
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
5.4.99.47
(S)-2,3-oxidosqualene
-
713760
Saccharomyces cerevisiae
parkeol + lanosterol + lanost-24-ene-3beta,9alpha-diol
lanosterol-synthase mutant T384Y produces 11% parkeol, 79% lanosterol and 10% lanost-24-ene-3beta,9alpha-diol from (S)-2,3-oxidosqualene
-
-
?
5.4.99.47
(S)-2,3-oxidosqualene
-
713760
Saccharomyces cerevisiae
parkeol + lanosterol + lanost-24-ene-3beta,9alpha-diol
lanosterol-synthase mutant T384Y/V4545L produces 60% parkeol, 20% lanosterol and 20% lanost-24-ene-3beta,9alpha-diol from (S)-2,3-oxidosqualene
-
-
?
5.4.99.47
(S)-2,3-oxidosqualene
-
713760
Saccharomyces cerevisiae
parkeol + lanosterol + lanost-24-ene-3beta,9alpha-diol
lanosterol-synthase mutant T384Y/V454I produces 64% parkeol, 13% lanosterol and 23% lanost-24-ene-3beta,9alpha-diol from (S)-2,3-oxidosqualene
-
-
?