EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.6.3.1 | (2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | (3Z)-3-(3,4-dihydroxybenzylidene)-5-nitro-1,3-dihydro-2H-indol-2-one | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | (3Z)-3-[4-hydroxy-3,5-di(propan-2-yl)benzylidene]-1,3-dihydro-2H-indol-2-one | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | 2,3,8,9-tetrahydroxy-5-(2-hydroxy-5-nitrobenzyl)phenanthridin-6(5H)-one | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | 2,3,8,9-tetrahydroxy-5-(3-nitrobenzyl)phenanthridin-6(5H)-one | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | 2,3,8,9-tetrahydroxy-5-(4-nitrobenzyl)phenanthridin-6(5H)-one | 93% inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | 2,3,8,9-tetrahydroxy-5-[2-(phenylsulfonyl)benzyl]phenanthridin-6(5H)-one | 95% inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | 2-(1,3-benzothiazol-2-yl)-4-ethyl-5-(2-methoxyethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione | - |
Homo sapiens | |
1.6.3.1 | 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-6-methoxy-4H-chromen-4-one | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one | 88% inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | 2-hydroxy-5-[(2-hydroxybenzyl)amino]benzoic acid | 89% inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | 2-[(2,3,8,9-tetrahydroxy-6-oxophenanthridin-5(6H)-yl)methyl]benzonitrile | 97% inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | 2-[(2E)-2-(3,4-dihydroxybenzylidene)hydrazinyl]-N-(3-nitrophenyl)-2-oxoacetamide | 96% inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | 3,5,7-trihydroxy-2-(4-hydroxy-3-methylphenyl)-4H-chromen-4-one | 94% inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | 3-(3,4-dihydroxycyclohexa-2,4-dien-1-yl)-2,7-dihydroxy-4H-chromen-4-one | 86% inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | 3-(3-chlorophenyl)-N-[4-(piperidin-4-yl)phenyl]pyrazolo[1,5-a]pyrimidine-5-carboxamide | - |
Homo sapiens | |
1.6.3.1 | 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | 5-[(2,5-dihydroxybenzyl)amino]-2-hydroxybenzoic acid | 82% inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | abruquinone C | - |
Homo sapiens | |
1.6.3.1 | apocynin | - |
Homo sapiens | |
1.6.3.1 | gliotoxin | - |
Homo sapiens | |
1.6.3.1 | gomisin C | - |
Homo sapiens | |
1.6.3.1 | honokiol | - |
Homo sapiens | |
1.6.3.1 | magnolol | - |
Homo sapiens | |
1.6.3.1 | methyl 2-hydroxy-5-[(2-hydroxybenzyl)amino]benzoate | 91% inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | N'1,N'2-bis[(E)-(2,3-dihydroxyphenyl)methylidene]ethanedihydrazide | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | N'1,N'2-bis[(E)-(3,4-dihydroxyphenyl)methylidene]ethanedihydrazide | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | N-(1-cyclohexylethyl)-4-phenylphthalazin-1-amine | - |
Homo sapiens | |
1.6.3.1 | N-(3-aminophenyl)-N'-[1-(4-hydroxy-3-methoxyphenyl)ethyl]ethanediamide | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | N-[(3Z)-3-(4-hydroxy-3-methoxybenzylidene)-2-oxo-2,3-dihydro-1H-indol-5-yl]acetamide | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | N-[1-(3,4-dihydroxyphenyl)ethyl]-N'-(3-nitrophenyl)ethanediamide | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | N4-(3-aminophenyl)[1]benzothieno[3,2-d]pyrimidine-4,8-diamine | 98% inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | N4-(4-aminophenyl)[1]benzothieno[3,2-d]pyrimidine-4,8-diamine | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | neopterin | - |
Homo sapiens | |
1.6.3.1 | norathyriol | - |
Homo sapiens | |
1.6.3.1 | perhexilline | - |
Homo sapiens | |
1.6.3.1 | prodigiosin | - |
Homo sapiens | |
1.6.3.1 | quercetin 3-O-alpha-D-glucopyranoside | complete inhibition at 0.01 mM | Homo sapiens | |
1.6.3.1 | S17834 | - |
Homo sapiens | |
1.6.3.1 | VAS2870 | - |
Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.6.3.1 | 65000 | - |
SDS-PAGE | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.6.3.1 | NADPH + H+ + O2 | Homo sapiens | - |
NADP+ + H2O2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.6.3.1 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.6.3.1 | 293-F FreeStyle cell | - |
Homo sapiens | - |
1.6.3.1 | HEK-293F cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.6.3.1 | NADPH + H+ + O2 | - |
Homo sapiens | NADP+ + H2O2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.6.3.1 | NADPH oxidase 4 | - |
Homo sapiens |
1.6.3.1 | Nox4 | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.6.3.1 | 0.00017 | - |
pH and temperature not specified in the publication | Homo sapiens | 2,3,8,9-tetrahydroxy-5-(2-hydroxy-5-nitrobenzyl)phenanthridin-6(5H)-one | |
1.6.3.1 | 0.00024 | - |
pH and temperature not specified in the publication | Homo sapiens | N4-(3-aminophenyl)[1]benzothieno[3,2-d]pyrimidine-4,8-diamine | |
1.6.3.1 | 0.00026 | - |
pH and temperature not specified in the publication | Homo sapiens | 2,3,8,9-tetrahydroxy-5-(3-nitrobenzyl)phenanthridin-6(5H)-one | |
1.6.3.1 | 0.00059 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[(2,3,8,9-tetrahydroxy-6-oxophenanthridin-5(6H)-yl)methyl]benzonitrile | |
1.6.3.1 | 0.00063 | - |
pH and temperature not specified in the publication | Homo sapiens | (3Z)-3-[4-hydroxy-3,5-di(propan-2-yl)benzylidene]-1,3-dihydro-2H-indol-2-one | |
1.6.3.1 | 0.00068 | - |
pH and temperature not specified in the publication | Homo sapiens | 3,5,7-trihydroxy-2-(4-hydroxy-3-methylphenyl)-4H-chromen-4-one | |
1.6.3.1 | 0.00074 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-6-methoxy-4H-chromen-4-one | |
1.6.3.1 | 0.00079 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(3,4-dihydroxycyclohexa-2,4-dien-1-yl)-2,7-dihydroxy-4H-chromen-4-one | |
1.6.3.1 | 0.00083 | - |
pH and temperature not specified in the publication | Homo sapiens | quercetin 3-O-alpha-D-glucopyranoside | |
1.6.3.1 | 0.00085 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one | |
1.6.3.1 | 0.00091 | - |
pH and temperature not specified in the publication | Homo sapiens | N'1,N'2-bis[(E)-(2,3-dihydroxyphenyl)methylidene]ethanedihydrazide | |
1.6.3.1 | 0.00096 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-hydroxy-5-[(2-hydroxybenzyl)amino]benzoic acid | |
1.6.3.1 | 0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | (2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide | |
1.6.3.1 | 0.00102 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[(2E)-2-(3,4-dihydroxybenzylidene)hydrazinyl]-N-(3-nitrophenyl)-2-oxoacetamide | |
1.6.3.1 | 0.00102 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one | |
1.6.3.1 | 0.00107 | - |
pH and temperature not specified in the publication | Homo sapiens | N4-(4-aminophenyl)[1]benzothieno[3,2-d]pyrimidine-4,8-diamine | |
1.6.3.1 | 0.00113 | - |
pH and temperature not specified in the publication | Homo sapiens | 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | |
1.6.3.1 | 0.00113 | - |
pH and temperature not specified in the publication | Homo sapiens | (3Z)-3-(3,4-dihydroxybenzylidene)-5-nitro-1,3-dihydro-2H-indol-2-one | |
1.6.3.1 | 0.00116 | - |
pH and temperature not specified in the publication | Homo sapiens | N'1,N'2-bis[(E)-(3,4-dihydroxyphenyl)methylidene]ethanedihydrazide | |
1.6.3.1 | 0.0012 | - |
pH and temperature not specified in the publication | Homo sapiens | 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | |
1.6.3.1 | 0.00127 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl 2-hydroxy-5-[(2-hydroxybenzyl)amino]benzoate | |
1.6.3.1 | 0.0013 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(3-aminophenyl)-N'-[1-(4-hydroxy-3-methoxyphenyl)ethyl]ethanediamide | |
1.6.3.1 | 0.00134 | - |
pH and temperature not specified in the publication | Homo sapiens | 5-[(2,5-dihydroxybenzyl)amino]-2-hydroxybenzoic acid | |
1.6.3.1 | 0.0014 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[(3Z)-3-(4-hydroxy-3-methoxybenzylidene)-2-oxo-2,3-dihydro-1H-indol-5-yl]acetamide | |
1.6.3.1 | 0.00158 | - |
pH and temperature not specified in the publication | Homo sapiens | 2,3,8,9-tetrahydroxy-5-(4-nitrobenzyl)phenanthridin-6(5H)-one | |
1.6.3.1 | 0.00158 | - |
pH and temperature not specified in the publication | Homo sapiens | 2,3,8,9-tetrahydroxy-5-[2-(phenylsulfonyl)benzyl]phenanthridin-6(5H)-one | |
1.6.3.1 | 0.00164 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[1-(3,4-dihydroxyphenyl)ethyl]-N'-(3-nitrophenyl)ethanediamide |