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Literature summary extracted from

  • Zhang, X.; Zhou, Z.; Yang, H.; Chen, J.; Feng, Y.; Du, L.; Leng, Y.; Shen, J.
    4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice (2009), Bioorg. Med. Chem. Lett., 19, 4455-4458.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.146 2-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
-
 Homo sapiens
1.1.1.146 2-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
-
 Mus musculus
1.1.1.146 3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-4-fluorobenzenesulfonamide
-
 Homo sapiens
1.1.1.146 3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-4-fluorobenzenesulfonamide
-
 Mus musculus
1.1.1.146 3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
-
 Homo sapiens
1.1.1.146 3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
-
 Mus musculus
1.1.1.146 3-chloro-N-[4-(morpholin-4-ylcarbonyl)benzyl]benzenesulfonamide
-
 Homo sapiens
1.1.1.146 3-chloro-N-[4-(morpholin-4-ylcarbonyl)benzyl]benzenesulfonamide
-
 Mus musculus
1.1.1.146 3-chloro-N-[4-(piperidin-1-ylcarbonyl)benzyl]benzenesulfonamide
-
 Homo sapiens
1.1.1.146 3-chloro-N-[4-(piperidin-1-ylcarbonyl)benzyl]benzenesulfonamide
-
 Mus musculus
1.1.1.146 3-chloro-N-[4-(pyrrolidin-1-ylcarbonyl)benzyl]benzenesulfonamide
-
 Homo sapiens
1.1.1.146 3-chloro-N-[4-(pyrrolidin-1-ylcarbonyl)benzyl]benzenesulfonamide
-
 Mus musculus
1.1.1.146 3-chloro-N-[4-[(4-methylpiperazin-1-yl)carbonyl]benzyl]benzenesulfonamide
-
 Homo sapiens
1.1.1.146 3-chloro-N-[4-[(4-methylpiperazin-1-yl)carbonyl]benzyl]benzenesulfonamide
-
 Mus musculus
1.1.1.146 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N,N-diethylbenzamide
-
 Homo sapiens
1.1.1.146 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N,N-diethylbenzamide
-
 Mus musculus
1.1.1.146 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-(tricyclo[3.3.1.13,7]dec-1-yl)benzamide
-
 Homo sapiens
1.1.1.146 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-(tricyclo[3.3.1.13,7]dec-1-yl)benzamide
-
 Mus musculus
1.1.1.146 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-methylbenzamide
-
 Homo sapiens
1.1.1.146 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-methylbenzamide
-
 Mus musculus
1.1.1.146 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-propylbenzamide
-
 Homo sapiens
1.1.1.146 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-propylbenzamide
-
 Mus musculus
1.1.1.146 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
-
 Homo sapiens
1.1.1.146 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
-
 Mus musculus
1.1.1.146 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclohexylbenzamide
-
 Homo sapiens
1.1.1.146 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclohexylbenzamide
-
 Mus musculus
1.1.1.146 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclopentylbenzamide
-
 Homo sapiens
1.1.1.146 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclopentylbenzamide
-
 Mus musculus
1.1.1.146 4-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
-
 Homo sapiens
1.1.1.146 4-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
-
 Mus musculus
1.1.1.146 glycyrrhizic acid
-
 Homo sapiens
1.1.1.146 glycyrrhizic acid
-
 Mus musculus
1.1.1.146 N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-3-(trifluoromethyl)benzenesulfonamide
-
 Homo sapiens
1.1.1.146 N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-3-(trifluoromethyl)benzenesulfonamide
-
 Mus musculus
1.1.1.146 N-butyl-4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
-
 Homo sapiens
1.1.1.146 N-butyl-4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens
-
-
-
1.1.1.146 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 adipose tissue
-
 Mus musculus
-
1.1.1.146 adipose tissue
-
 Homo sapiens
-
1.1.1.146 liver
-
 Mus musculus
-
1.1.1.146 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisone + NADPH + H+
-
 Mus musculus cortisol + NADP+
-
 ?
1.1.1.146 cortisone + NADPH + H+
-
 Homo sapiens cortisol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Mus musculus
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.146 0.000002
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-methylbenzamide
1.1.1.146 0.000002
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-propylbenzamide
1.1.1.146 0.000002
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-propylbenzamide
1.1.1.146 0.000002
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus N-butyl-4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
1.1.1.146 0.000008
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus glycyrrhizic acid
1.1.1.146 0.00001
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens glycyrrhizic acid
1.1.1.146 0.00001
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-(tricyclo[3.3.1.13,7]dec-1-yl)benzamide
1.1.1.146 0.000014
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-(tricyclo[3.3.1.13,7]dec-1-yl)benzamide
1.1.1.146 0.000015
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
1.1.1.146 0.000047
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens N-butyl-4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
1.1.1.146 0.000049
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
1.1.1.146 0.000131
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus 3-chloro-N-[4-(piperidin-1-ylcarbonyl)benzyl]benzenesulfonamide
1.1.1.146 0.000302
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclohexylbenzamide
1.1.1.146 0.000395
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N,N-diethylbenzamide
1.1.1.146 0.000411
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclohexylbenzamide
1.1.1.146 0.00048
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus 3-chloro-N-[4-(pyrrolidin-1-ylcarbonyl)benzyl]benzenesulfonamide
1.1.1.146 0.000576
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus 3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
1.1.1.146 0.000638
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-methylbenzamide
1.1.1.146 0.000647
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-chloro-N-[4-(piperidin-1-ylcarbonyl)benzyl]benzenesulfonamide
1.1.1.146 0.000732
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclopentylbenzamide
1.1.1.146 0.001024
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus 3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-4-fluorobenzenesulfonamide
1.1.1.146 0.00113
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
1.1.1.146 0.001208
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-3-(trifluoromethyl)benzenesulfonamide
1.1.1.146 0.001319
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus 3-chloro-N-[4-[(4-methylpiperazin-1-yl)carbonyl]benzyl]benzenesulfonamide
1.1.1.146 0.001404
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus 4-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
1.1.1.146 0.001672
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
1.1.1.146 0.001733
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-chloro-N-[4-(pyrrolidin-1-ylcarbonyl)benzyl]benzenesulfonamide
1.1.1.146 0.002106
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N,N-diethylbenzamide
1.1.1.146 0.002631
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-4-fluorobenzenesulfonamide
1.1.1.146 0.002698
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
1.1.1.146 0.003379
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus 3-chloro-N-[4-(morpholin-4-ylcarbonyl)benzyl]benzenesulfonamide
1.1.1.146 0.005614
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-3-(trifluoromethyl)benzenesulfonamide
1.1.1.146 0.005843
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus 2-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
1.1.1.146 0.008512
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclopentylbenzamide
1.1.1.146 0.01449
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-chloro-N-[4-(morpholin-4-ylcarbonyl)benzyl]benzenesulfonamide
1.1.1.146 0.0159
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-chloro-N-[4-[(4-methylpiperazin-1-yl)carbonyl]benzyl]benzenesulfonamide