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Literature summary extracted from
- The yeast Candida albicans evades human complement attack by secretion of aspartic proteases (2009), Mol. Immunol., 47, 465-475.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.23.24 | expressed in Pichia pastoris | Candida albicans |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.23.24 | Aprotinin | - |
Candida albicans |  |
| 3.4.23.24 | pepstatin A | - |
Candida albicans | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.23.24 | 38000 | - |
isoform Sap3, SDS-PAGE | Candida albicans |
| 3.4.23.24 | 41000 | - |
isoform Sap2, SDS-PAGE | Candida albicans |
| 3.4.23.24 | 42000 | - |
isoform Sap1, SDS-PAGE | Candida albicans |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.23.24 | Candida albicans | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.23.24 | casein + H2O | isoforms Sap1, Sap2, Sap3, and Sap9 cleave casein | Candida albicans | ? | - |
? | |
| 3.4.23.24 | complement components C3b + H2O | substrate for isoforms Sap1, Sap2, Sap3, but not for Sap9 | Candida albicans | ? | - |
? | |
| 3.4.23.24 | complement components C4b + H2O | substrate for isoforms Sap1, Sap2, Sap3, but not for Sap9 | Candida albicans | ? | - |
? | |
| 3.4.23.24 | complement components C5 + H2O | substrate for isoforms Sap1, Sap2, Sap3, but not for Sap9 | Candida albicans | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.23.24 | SAP | - |
Candida albicans |
| 3.4.23.24 | SAP1 | isoform | Candida albicans |
| 3.4.23.24 | SAP2 | isoform | Candida albicans |
| 3.4.23.24 | SAP3 | isoform | Candida albicans |
| 3.4.23.24 | Sap9 | isoform | Candida albicans |
| 3.4.23.24 | secreted aspartic protease | - |
Candida albicans |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.23.24 | physiological function | isoforms Sap1, Sap2, and Sap3 degrade host complement components C3b, C4b and C5 and suppress host complement response. Saps inhibit C3b opsonization of Candida albicans and generation of the anaphylatoxin C5a in human plasma | Candida albicans |
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Release 2023.1 (January 2023)
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