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Literature summary extracted from

  • Nicolaou, P.; Hajjar, R.J.; Kranias, E.G.
    Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiology (2009), J. Mol. Cell. Cardiol., 47, 365-371.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.3.16 medicine protein phosphatase inhibitor-1-based therapeutic interventions may ameliorate cardiac dysfunction and remodeling in the failing heart, mechanism and mode of action, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.16 protein phosphatase-1 inhibitor-1 plays a role in cardiac physiology and pathophysiology, overview Cavia porcellus
3.1.3.16 protein phosphatase-1 inhibitor-1 plays a role in cardiac physiology and pathophysiology, overview Homo sapiens
3.1.3.16 protein phosphatase-1 inhibitor-1 plays a role in cardiac physiology and pathophysiology, overview Mus musculus
3.1.3.16 protein phosphatase-1 inhibitor-1 plays a role in cardiac physiology and pathophysiology, overview Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.16 sarcoplasmic reticulum
-
 Cavia porcellus 16529
-
3.1.3.16 sarcoplasmic reticulum
-
 Mus musculus 16529
-
3.1.3.16 sarcoplasmic reticulum
-
 Homo sapiens 16529
-
3.1.3.16 sarcoplasmic reticulum
-
 Rattus norvegicus 16529
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.16 Ca2+ dependent on Cavia porcellus
3.1.3.16 Ca2+ dependent on Mus musculus
3.1.3.16 Ca2+ dependent on Homo sapiens
3.1.3.16 Ca2+ dependent on Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.16 phosphorylated lamban + H2O Cavia porcellus the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?
3.1.3.16 phosphorylated lamban + H2O Mus musculus the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?
3.1.3.16 phosphorylated lamban + H2O Homo sapiens the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?
3.1.3.16 phosphorylated lamban + H2O Rattus norvegicus the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Cavia porcellus
-
-
-
3.1.3.16 Homo sapiens
-
-
-
3.1.3.16 Mus musculus
-
-
-
3.1.3.16 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.16 cardiomyocyte
-
 Homo sapiens
-
3.1.3.16 heart
-
 Cavia porcellus
-
3.1.3.16 heart
-
 Mus musculus
-
3.1.3.16 heart
-
 Homo sapiens
-
3.1.3.16 heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 phosphorylated lamban + H2O
-
 Cavia porcellus lamban + phosphate
-
 ?
3.1.3.16 phosphorylated lamban + H2O
-
 Mus musculus lamban + phosphate
-
 ?
3.1.3.16 phosphorylated lamban + H2O
-
 Homo sapiens lamban + phosphate
-
 ?
3.1.3.16 phosphorylated lamban + H2O
-
 Rattus norvegicus lamban + phosphate
-
 ?
3.1.3.16 phosphorylated lamban + H2O the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview Cavia porcellus lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?
3.1.3.16 phosphorylated lamban + H2O the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview Mus musculus lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?
3.1.3.16 phosphorylated lamban + H2O the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview Homo sapiens lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?
3.1.3.16 phosphorylated lamban + H2O the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview Rattus norvegicus lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.16 PP1
-
 Cavia porcellus
3.1.3.16 PP1
-
 Mus musculus
3.1.3.16 PP1
-
 Homo sapiens
3.1.3.16 PP1
-
 Rattus norvegicus
3.1.3.16 PP2A
-
 Homo sapiens
3.1.3.16 protein phosphatase-1
-
 Cavia porcellus
3.1.3.16 protein phosphatase-1
-
 Mus musculus
3.1.3.16 protein phosphatase-1
-
 Homo sapiens
3.1.3.16 protein phosphatase-1
-
 Rattus norvegicus
3.1.3.16 type 1 protein phosphatase
-
 Cavia porcellus
3.1.3.16 type 1 protein phosphatase
-
 Mus musculus
3.1.3.16 type 1 protein phosphatase
-
 Homo sapiens
3.1.3.16 type 1 protein phosphatase
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.1.3.16 malfunction perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview Cavia porcellus
3.1.3.16 malfunction perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview Mus musculus
3.1.3.16 malfunction perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview Homo sapiens
3.1.3.16 malfunction perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview Rattus norvegicus
3.1.3.16 physiological function type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview Cavia porcellus
3.1.3.16 physiological function type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview Mus musculus
3.1.3.16 physiological function type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview Homo sapiens
3.1.3.16 physiological function type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview Rattus norvegicus