BRENDA - Enzyme Database

Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner

Idkowiak-Baldys, J.; Baldys, A.; Raymond, J.R.; Hannun, Y.A.; J. Biol. Chem. 284, 22322-22331 (2009)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
3.1.4.4
expressed in C-6 glioma cells
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.4
1-butanol
-
Homo sapiens
3.1.4.4
additional information
no inhibition by 2-butanol
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.4.4
plasma membrane
-
Homo sapiens
5886
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.4.4
Homo sapiens
-
isozymes PLD1 and PLD2
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.4
HEK-293 cell
-
Homo sapiens
-
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.4.4
expressed in C-6 glioma cells
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.4
1-butanol
-
Homo sapiens
3.1.4.4
additional information
no inhibition by 2-butanol
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.4.4
plasma membrane
-
Homo sapiens
5886
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.4
HEK-293 cell
-
Homo sapiens
-
General Information
EC Number
General Information
Commentary
Organism
3.1.4.4
additional information
stimulation of the serotonin 5-HT2A receptor and the angiotensin II receptor, AT1AR, two G-protein-coupled receptors, leads to their sequestration from endosomes to into a Rab11-positive juxtanuclear compartment in a PKC- and PLD-dependent manner, detailed overview. The PKC- and PLD-dependent sequestration of receptors results in co-sequestration of other plasma membrane proteins and receptors, e.g. of epidermal growth factor receptor and protease activated receptor-1
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.1.4.4
additional information
stimulation of the serotonin 5-HT2A receptor and the angiotensin II receptor, AT1AR, two G-protein-coupled receptors, leads to their sequestration from endosomes to into a Rab11-positive juxtanuclear compartment in a PKC- and PLD-dependent manner, detailed overview. The PKC- and PLD-dependent sequestration of receptors results in co-sequestration of other plasma membrane proteins and receptors, e.g. of epidermal growth factor receptor and protease activated receptor-1
Homo sapiens