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Literature summary extracted from

  • Tonhosolo, R.; D'Alexandri, F.L.; Genta, F.A.; Wunderlich, G.; Gozzo, F.C.; Eberlin, M.N.; Peres, V.J.; Kimura, E.A.; Katzin, A.M.
    Identification, molecular cloning and functional characterization of an octaprenyl pyrophosphate synthase in intra-erythrocytic stages of Plasmodium falciparum (2005), Biochem. J., 392, 117-126.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.90 expression as glutathione-S-transferase fusion protein Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.90 nerolidol competitive, 57% inhibition at 50 nM Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.90 0.0011
-
 (2E,6E)-farnesyl diphosphate pH 7.5, 30°C Plasmodium falciparum
2.5.1.90 0.0024
-
 isopentenyl diphosphate pH 7.5, 30°C Plasmodium falciparum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.90 63000
-
 x * 63000, SDS-PAGE of recombinant enzyme Plasmodium falciparum

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.90 Plasmodium falciparum O96130
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.90 partial, from schizont stage parasite Plasmodium falciparum

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.90 schizont
-
 Plasmodium falciparum
-
2.5.1.90 trophozoite
-
 Plasmodium falciparum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.90 (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate
-
 Plasmodium falciparum 5 diphosphate + all-trans-octaprenyl diphosphate
-
 ?
2.5.1.90 (2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
-
 Plasmodium falciparum 6 diphosphate + all-trans-nonaprenyl diphosphate
-
 ?
2.5.1.90 additional information no substrate: geranyl diphosphate, geranylgeranyl diphosphate Plasmodium falciparum ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.90 ? x * 63000, SDS-PAGE of recombinant enzyme Plasmodium falciparum

Synonyms

EC Number Synonyms Comment Organism
2.5.1.90 octaprenyl pyrophosphate synthase
-
 Plasmodium falciparum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.90 0.000015
-
 nerolidol pH 7.5, 30°C Plasmodium falciparum