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Literature summary extracted from

  • Walker, L.; Munro, C.; De Bruijn, I.; Lenardon, M.; McKinnon, A.; Gow, N.
    Stimulation of chitin synthesis rescues Candida albicans from echinocandins (2008), PLoS Pathog., 4, e1000040.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.16 Candida albicans
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Expression

EC Number Organism Comment Expression
2.4.1.16 Candida albicans treatment of Candida albicans with low levels of echinocandins such as caspofungin, echinocandin B, cilofungin and anidulafungin stimulates chitin synthase gene expression, increases Chs activity, elevates chitin content and reduced efficacy of these drugs up

General Information

EC Number General Information Comment Organism
2.4.1.16 physiological function treatment of Candida albicans with low levels of echinocandins such as caspofungin, echinocandin B, cilofungin and anidulafungin stimulates chitin synthase gene expression, increases Chs activity, elevates chitin content and reduced efficacy of these drugs. Elevation of chitin synthesis is mediated via the PKC, HOG, and Ca2+-calcineurin signalling pathways. Stimulation of isoforms Chs2p and Chs8p by activators of these pathways enables cells to survive otherwise lethal concentrations of echinocandins, even in the absence of Chs3p and the normally essential Chs1p, which synthesize the chitinous septal ring and primary septum of the fungus. Under such conditions, a novel proximally offset septum is synthesized that restores the capacity for cell division, sustaines the viability of the cell, and abrogates morphological and growth defects associated with echinocandin treatment and the chs mutations Candida albicans