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Literature summary extracted from

  • Kumar, M.; Vijayakrishnan, R.; Subba Rao, G.
    In silico structure-based design of a novel class of potent and selective small peptide inhibitor of Mycobacterium tuberculosis dihydrofolate reductase, a potential target for anti-TB drug discovery (2010), Mol. Divers., 14, 5955-60.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.5.1.3 drug development mtDHFR is an attractive target for the development of anti-tuberculosis drugs Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.3 L-tryptophyl-L-tyrosyl-L-tyrosine development of a tri-peptide inhibitor using a structure-based drug design approach, docking studies and molecular dynamics, overview Mycobacterium tuberculosis
1.5.1.3 methotrexate
-
 Mycobacterium tuberculosis
1.5.1.3 pyrimethamine
-
 Mycobacterium tuberculosis
1.5.1.3 trimethoprim weak inhibition Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.3 7,8-dihydrofolate + NADPH + H+ Mycobacterium tuberculosis the reaction is essential in DNA synthesis 5,6,7,8-tetrahydrofolate + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.3 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.3 7,8-dihydrofolate + NADPH + H+
-
 Mycobacterium tuberculosis 5,6,7,8-tetrahydrofolate + NADP+
-
 ?
1.5.1.3 7,8-dihydrofolate + NADPH + H+ the reaction is essential in DNA synthesis Mycobacterium tuberculosis 5,6,7,8-tetrahydrofolate + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.3 DHFR
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.3 NADPH
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
1.5.1.3 malfunction inhibition of the enzyme activity leads to arrest of DNA synthesis and hence cell death Mycobacterium tuberculosis
1.5.1.3 physiological function tetrahydrofolate is a precursor of cofactors necessary for the synthesis of thymidylate, purine nucleotides,methionine, serine, and glycine required for DNA, RNA, and protein synthesis Mycobacterium tuberculosis