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Literature summary extracted from

  • Hammerschmidt, F.; Kählig, H.
    Biosynthesis of natural products with a P-C Bond. 7. Synthesis of [1,1-2H2]-, [2,2-2H2]-, (R)- and (S)-[2 H1](2-hydroxyethyl)phosphonic acid and (R,S)-[1-2H1](1,2-dihydroxyethyl)phosphonic acid and incorporation studies into fosfomycin in Streptomyces fradiae (1991), J. Org. Chem., 56, 2364-2370.
No PubMed abstract available

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.308 Streptomyces fradiae D2SNF5
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.308 (2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin (S)- and (R)-(2-hydroxy[1-2H1]ethyl)phosphonic acids are fed to Streptomyces fradiae. The deuterium of (R)-(2-hydroxy[1-2H1]ethyl)phosphonic acid is lost, and the deuterium of (S)-(2-hydroxy[1-2H1]ethyl)phosphonic acid is retained on incorporation into fosfomycin Streptomyces fradiae (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin
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