EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
6.3.5.2 | additional information | construction of disruption mutants, the heterozygote GUA1/gua1 strain is hypersensitive to 6-azauracil, a known inhibitor of the IMP dehydrogenase involved in GMP biosynthesis. In a murine model of systemic candidiasis, the virulence of the heterozygous strain is marginally attenuated, while the homozygous mutant gua1/gua1 strain is completely avirulent | Candida albicans |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.3.5.2 | Candida albicans | - |
strain CAI4, gene GUA1 | - |
6.3.5.2 | Candida albicans CAI-4 | - |
strain CAI4, gene GUA1 | - |