Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Fotopoulou, S.; Oikonomou, N.; Grigorieva, E.; Nikitopoulou, I.; Paparountas, T.; Thanassopoulou, A.; Zhao, Z.; Xu, Y.; Kontoyiannis, D.L.; Remboutsika, E.; Aidinis, V.
    ATX expression and LPA signalling are vital for the development of the nervous system (2010), Dev. Biol., 339, 451-464.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.39 lysophosphatidylcholine + H2O Mus musculus
-
 lysophosphatidic acid + choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.39 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.39 blood plasma
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.39 FS-3 + H2O
-
 Mus musculus ?
-
 ?
3.1.4.39 lysophosphatidylcholine + H2O
-
 Mus musculus lysophosphatidic acid + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.39 ATX
-
 Mus musculus
3.1.4.39 autotaxin
-
 Mus musculus
3.1.4.39 ENPP2
-
 Mus musculus
3.1.4.39 lysophospholipase D
-
 Mus musculus
3.1.4.39 lysoPLD
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.1.4.39 malfunction E9.5 ATX null mutants exhibit a failure of neural tube closure, most likely independent of the circulatory failure, which correlates with decreased cell proliferation and increased cell death, obligatory deletion results to embryonic lethality most likely due to aberrant vascular branching morphogenesis and chorio-allantoic fusion Mus musculus
3.1.4.39 physiological function ATX expression and lysophosphatidic acid signalling are vital for the development of the nervous system, ATX and lysophosphatidic acid are necessary for embryonic HIF-1a expression Mus musculus