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Literature summary extracted from

  • Hirata, A.; Murakami, K.S.
    Archaeal RNA polymerase (2009), Curr. Opin. Struct. Biol., 19, 724-731.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.6 additional information the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS Pyrococcus furiosus
2.7.7.6 additional information the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS Saccharolobus solfataricus
2.7.7.6 additional information the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS Saccharolobus shibatae
2.7.7.6 additional information the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS Methanocaldococcus jannaschii
2.7.7.6 additional information the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS Archaeoglobus fulgidus
2.7.7.6 additional information the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS Thermococcus kodakarensis
2.7.7.6 additional information the Pol II transcription apparatus requires the transcription factors TBP, TFIIB, TFIIEalpha and TFIIS Saccharomyces cerevisiae
2.7.7.6 additional information the Pol II transcription apparatus requires the transcription factors TBP, TFIIB, TFIIEalpha and TFIIS Schizosaccharomyces pombe

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.7.6 crystal structure determination Pyrococcus furiosus
2.7.7.6 crystal structure determination Saccharolobus shibatae
2.7.7.6 crystal structure determination Archaeoglobus fulgidus
2.7.7.6 crystal structure determination, structure including the A' subunit jaw and clamp head domains and RpoG and Rpo13 subunits Saccharolobus solfataricus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.6 Iron RNA polymerase is a member of the iron-sulfur cluster protein family Homo sapiens
2.7.7.6 Iron RNA polymerase is a member of the iron-sulfur cluster protein family Saccharomyces cerevisiae
2.7.7.6 Iron RNA polymerase is a member of the iron-sulfur cluster protein family Schizosaccharomyces pombe
2.7.7.6 Iron RNA polymerase is a member of the iron-sulfur cluster protein family and contains one 4Fe-4S cluster binding motif Saccharolobus solfataricus
2.7.7.6 Iron RNA polymerase is a member of the iron-sulfur cluster protein family and contains one 4Fe-4S cluster binding motif Saccharolobus shibatae
2.7.7.6 Iron RNA polymerase is a member of the iron-sulfur cluster protein family and contains two 4Fe-4S cluster binding motifs Archaeoglobus fulgidus
2.7.7.6 Mg2+ the enzyme active site is located on the back wall of the channel, where an essential Mg2+ ion is chelated by three Asp of the absolutely conserved NADFDGD motif in the A' subunit Saccharolobus solfataricus
2.7.7.6 additional information the Pyrococcus RNA polymerase does not contain iron-sulfur cluster binding motifs Pyrococcus furiosus
2.7.7.6 additional information the Thermococcus RNA polymerase does not contain iron-sulfur cluster binding motifs Thermococcus kodakarensis

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.6 Archaeoglobus fulgidus
-
-
-
2.7.7.6 Homo sapiens
-
-
-
2.7.7.6 Methanocaldococcus jannaschii
-
-
-
2.7.7.6 Pyrococcus furiosus
-
-
-
2.7.7.6 Saccharolobus shibatae
-
-
-
2.7.7.6 Saccharolobus solfataricus
-
-
-
2.7.7.6 Saccharomyces cerevisiae
-
-
-
2.7.7.6 Schizosaccharomyces pombe
-
-
-
2.7.7.6 Thermococcus kodakarensis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.6 additional information the enzyme active site is located on the back wall of the channel, where an essential Mg2+ ion is chelated by three Asp of the absolutely conserved NADFDGD motif in the A' subunit Saccharolobus solfataricus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.6 More structure analysis and modeling, overview Saccharolobus shibatae
2.7.7.6 More structure analysis, overview, the enzyme contains a subunit Rpo13 located at a groove between the H subunit and the clamp head domain of the A' subunit, model ing including the A' subunit jaw and clamp head domains and RpoG and Rpo13, overview Saccharolobus solfataricus
2.7.7.6 More the enzyme lacks the Rpb8 and Rpo13 subunits Pyrococcus furiosus

Synonyms

EC Number Synonyms Comment Organism
2.7.7.6 More RNA polymerase is a member of the iron-sulfur cluster protein family Homo sapiens
2.7.7.6 More RNA polymerase is a member of the iron-sulfur cluster protein family Saccharomyces cerevisiae
2.7.7.6 More RNA polymerase is a member of the iron-sulfur cluster protein family Schizosaccharomyces pombe
2.7.7.6 More RNA polymerase is a member of the iron-sulfur cluster protein family Saccharolobus solfataricus
2.7.7.6 More RNA polymerase is a member of the iron-sulfur cluster protein family Saccharolobus shibatae
2.7.7.6 More RNA polymerase is a member of the iron-sulfur cluster protein family Methanocaldococcus jannaschii
2.7.7.6 More RNA polymerase is a member of the iron-sulfur cluster protein family Archaeoglobus fulgidus
2.7.7.6 Pol II
-
 Saccharomyces cerevisiae
2.7.7.6 Pol II
-
 Schizosaccharomyces pombe
2.7.7.6 RNA polymerase
-
 Homo sapiens
2.7.7.6 RNA polymerase
-
 Saccharomyces cerevisiae
2.7.7.6 RNA polymerase
-
 Pyrococcus furiosus
2.7.7.6 RNA polymerase
-
 Schizosaccharomyces pombe
2.7.7.6 RNA polymerase
-
 Saccharolobus solfataricus
2.7.7.6 RNA polymerase
-
 Saccharolobus shibatae
2.7.7.6 RNA polymerase
-
 Methanocaldococcus jannaschii
2.7.7.6 RNA polymerase
-
 Archaeoglobus fulgidus
2.7.7.6 RNA polymerase
-
 Thermococcus kodakarensis
2.7.7.6 RNAP
-
 Homo sapiens
2.7.7.6 RNAP
-
 Saccharomyces cerevisiae
2.7.7.6 RNAP
-
 Pyrococcus furiosus
2.7.7.6 RNAP
-
 Schizosaccharomyces pombe
2.7.7.6 RNAP
-
 Saccharolobus solfataricus
2.7.7.6 RNAP
-
 Saccharolobus shibatae
2.7.7.6 RNAP
-
 Methanocaldococcus jannaschii
2.7.7.6 RNAP
-
 Archaeoglobus fulgidus
2.7.7.6 RNAP
-
 Thermococcus kodakarensis

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.7.6 Fe-S cluster with 4Fe-4S cluster-binding motif Saccharolobus solfataricus