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Literature summary extracted from

  • Koyanagi, T.; Katayama, T.; Suzuki, H.; Onishi, A.; Yokozeki, K.; Kumagai, H.
    Hyperproduction of 3,4-dihydroxyphenyl-L-alanine (L-Dopa) using Erwinia herbicola cells carrying a mutant transcriptional regulator TyrR (2009), Biosci. Biotechnol. Biochem., 73, 1221-1223.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
4.1.99.2 Pantoea agglomerans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.99.2 catechol + pyruvate + NH3
-
 Pantoea agglomerans 3,4-dihydroxyphenyl-L-alanine
-
 r
4.1.99.2 L-tyrosine + H2O
-
 Pantoea agglomerans phenol + pyruvate + NH3
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.1.99.2 TPL
-
 Pantoea agglomerans
4.1.99.2 tyrosine phenol-lyase
-
 Pantoea agglomerans

Expression

EC Number Organism Comment Expression
4.1.99.2 Pantoea agglomerans TyrR is the transcriptional activator of Tpl. Amino acid substitutions of TyrR, V67A, Y72C and E201G in the N-terminal domain, N324D in the central domain, A503T in the C-terminal domain, all enhance Tpl expression up

General Information

EC Number General Information Comment Organism
4.1.99.2 physiological function hyper-3,4-dihydroxyphenyl-L-alanine-producing strain by a mutant TyrR, an activator of tpl, whereby highest productivity is obtained for the strain grown under non-induced conditions, which is 30fold higher than that obtained for tyrosine-induced wild-type cells Pantoea agglomerans