EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.3 | (E)-5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | DHFR binding structure, modelling, overview | Homo sapiens | |
1.5.1.3 | (E)-5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | DHFR binding structure, modelling, overview | Mus musculus | |
1.5.1.3 | (Z)-5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | DHFR binding structure, modelling, overview | Homo sapiens | |
1.5.1.3 | (Z)-5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | DHFR binding structure, modelling, overview | Mus musculus | |
1.5.1.3 | 5-[(R/S)-2-(2'-methoxyphenyl)-3-methylbutyl]furo[2,3-d]-pyrimidine-2,4-diamine | - |
Homo sapiens | |
1.5.1.3 | 5-[(R/S)-2-(2'-methoxyphenyl)-3-methylbutyl]furo[2,3-d]-pyrimidine-2,4-diamine | - |
Mus musculus | |
1.5.1.3 | 5-[(R/S)-2-(2'-methoxyphenyl)-3-methylpentyl]furo[2,3-d]pyrimidine-2,4-diamine | - |
Homo sapiens | |
1.5.1.3 | 5-[(R/S)-2-(2'-methoxyphenyl)-3-methylpentyl]furo[2,3-d]pyrimidine-2,4-diamine | - |
Mus musculus | |
1.5.1.3 | 5-[(R/S)-2-(2'-methoxyphenyl)-4-methylpentyl]furo[2,3-d]pyrimidine-2,4-diamine | - |
Homo sapiens | |
1.5.1.3 | 5-[(R/S)-2-(2'-methoxyphenyl)-4-methylpentyl]furo[2,3-d]pyrimidine-2,4-diamine | - |
Mus musculus | |
1.5.1.3 | 5-[(R/S)-2-(2'-methoxyphenyl)hexyl]furo[2,3-d]pyrimidine-2,4-diamine | - |
Homo sapiens | |
1.5.1.3 | 5-[(R/S)-2-(2'-methoxyphenyl)hexyl]furo[2,3-d]pyrimidine-2,4-diamine | - |
Mus musculus | |
1.5.1.3 | 5-[(R/S)-2-(2'-methoxyphenyl)pentyl]furo[2,3-d]pyrimidine-2,4-diamine | - |
Homo sapiens | |
1.5.1.3 | 5-[(R/S)-2-(2'-methoxyphenyl)pentyl]furo[2,3-d]pyrimidine-2,4-diamine | - |
Mus musculus | |
1.5.1.3 | 5-[(R/S)-2-cyclopropyl-2-(2'-methoxyphenyl)ethyl]furo-[2,3-d]pyrimidine-2,4-diamine | - |
Homo sapiens | |
1.5.1.3 | 5-[(R/S)-2-cyclopropyl-2-(2'-methoxyphenyl)ethyl]furo-[2,3-d]pyrimidine-2,4-diamine | - |
Mus musculus | |
1.5.1.3 | 5-[(Z/E)-2-(2'-methoxyphenyl)-3-methylbut-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | - |
Homo sapiens | |
1.5.1.3 | 5-[(Z/E)-2-(2'-methoxyphenyl)-3-methylbut-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | - |
Mus musculus | |
1.5.1.3 | 5-[(Z/E)-2-(2'-methoxyphenyl)-3-methylpent-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | - |
Homo sapiens | |
1.5.1.3 | 5-[(Z/E)-2-(2'-methoxyphenyl)-3-methylpent-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | - |
Mus musculus | |
1.5.1.3 | 5-[(Z/E)-2-(2'-methoxyphenyl)-4-methylpent-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | - |
Homo sapiens | |
1.5.1.3 | 5-[(Z/E)-2-(2'-methoxyphenyl)-4-methylpent-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | - |
Mus musculus | |
1.5.1.3 | 5-[(Z/E)-2-(2'-methoxyphenyl)hex-1-en-1-yl]furo[2,3-d]-pyrimidine-2,4-diamine | - |
Homo sapiens | |
1.5.1.3 | 5-[(Z/E)-2-(2'-methoxyphenyl)hex-1-en-1-yl]furo[2,3-d]-pyrimidine-2,4-diamine | - |
Mus musculus | |
1.5.1.3 | 5-[(Z/E)-2-(2'-methoxyphenyl)pent-1-en-1-yl]furo[2,3-d]-pyrimidine-2,4-diamine | - |
Homo sapiens | |
1.5.1.3 | 5-[(Z/E)-2-(2'-methoxyphenyl)pent-1-en-1-yl]furo[2,3-d]-pyrimidine-2,4-diamine | - |
Mus musculus | |
1.5.1.3 | 5-[(Z/E)-2-cyclopropyl-2-(2'-methoxyphenyl)vinyl]furo-[2,3-d]pyrimidine-2,4-diamine | - |
Homo sapiens | |
1.5.1.3 | 5-[(Z/E)-2-cyclopropyl-2-(2'-methoxyphenyl)vinyl]furo-[2,3-d]pyrimidine-2,4-diamine | - |
Mus musculus | |
1.5.1.3 | additional information | synthesis and evaluation of 2,4-diaminofuro[2,3-d]pyrimidine inhibitors, overview | Homo sapiens | |
1.5.1.3 | additional information | synthesis and evaluation of 2,4-diaminofuro[2,3-d]pyrimidine inhibitors, overview | Mus musculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.3 | 0.0003 | - |
7,8-dihydrofolate | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.00242 | - |
NADPH | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.0027 | - |
7,8-dihydrofolate | pH 7.4, 37°C | Homo sapiens | |
1.5.1.3 | 0.004 | - |
NADPH | pH 7.4, 37°C | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.3 | 7,8-dihydrofolate + NADPH + H+ | Homo sapiens | - |
5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.3 | Homo sapiens | - |
- |
- |
1.5.1.3 | Mus musculus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.3 | 7,8-dihydrofolate + NADPH + H+ | - |
Homo sapiens | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
1.5.1.3 | dihydrofolate + NADPH + H+ | - |
Mus musculus | tetrahydrofolate + NADP+ | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.5.1.3 | DHFR | - |
Mus musculus |
1.5.1.3 | DHFR | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.5.1.3 | 37 | - |
assay at | Mus musculus |
1.5.1.3 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.5.1.3 | 7.4 | - |
assay at | Mus musculus |
1.5.1.3 | 7.4 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.3 | NADP+ | - |
Mus musculus | |
1.5.1.3 | NADPH | - |
Mus musculus | |
1.5.1.3 | NADPH | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.3 | 0.00006 | - |
5-[(R/S)-2-(2'-methoxyphenyl)-3-methylbutyl]furo[2,3-d]-pyrimidine-2,4-diamine | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.00006 | - |
5-[(R/S)-2-cyclopropyl-2-(2'-methoxyphenyl)ethyl]furo-[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.000062 | - |
(E)-5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.00007 | - |
5-[(Z/E)-2-(2'-methoxyphenyl)-3-methylbut-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.00007 | - |
5-[(Z/E)-2-(2'-methoxyphenyl)-3-methylpent-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.00008 | - |
5-[(Z/E)-2-cyclopropyl-2-(2'-methoxyphenyl)vinyl]furo-[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.00014 | - |
5-[(Z/E)-2-(2'-methoxyphenyl)pent-1-en-1-yl]furo[2,3-d]-pyrimidine-2,4-diamine | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.00016 | - |
(Z)-5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.0005 | - |
(E)-5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Homo sapiens | |
1.5.1.3 | 0.00055 | - |
5-[(Z/E)-2-(2'-methoxyphenyl)hex-1-en-1-yl]furo[2,3-d]-pyrimidine-2,4-diamine | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.00062 | - |
5-[(R/S)-2-(2'-methoxyphenyl)-4-methylpentyl]furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.00065 | - |
5-[(R/S)-2-cyclopropyl-2-(2'-methoxyphenyl)ethyl]furo-[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Homo sapiens | |
1.5.1.3 | 0.00077 | - |
5-[(R/S)-2-(2'-methoxyphenyl)-3-methylbutyl]furo[2,3-d]-pyrimidine-2,4-diamine | pH 7.4, 37°C | Homo sapiens | |
1.5.1.3 | 0.00078 | - |
5-[(R/S)-2-(2'-methoxyphenyl)-3-methylpentyl]furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.00083 | - |
5-[(Z/E)-2-(2'-methoxyphenyl)-3-methylbut-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Homo sapiens | |
1.5.1.3 | 0.00091 | - |
5-[(Z/E)-2-(2'-methoxyphenyl)-4-methylpent-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.0011 | - |
5-[(Z/E)-2-(2'-methoxyphenyl)-3-methylpent-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Homo sapiens | |
1.5.1.3 | 0.0013 | - |
5-[(Z/E)-2-cyclopropyl-2-(2'-methoxyphenyl)vinyl]furo-[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Homo sapiens | |
1.5.1.3 | 0.0016 | - |
(Z)-5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Homo sapiens | |
1.5.1.3 | 0.0016 | - |
5-[(Z/E)-2-(2'-methoxyphenyl)pent-1-en-1-yl]furo[2,3-d]-pyrimidine-2,4-diamine | pH 7.4, 37°C | Homo sapiens | |
1.5.1.3 | 0.0025 | - |
5-[(R/S)-2-(2'-methoxyphenyl)pentyl]furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Homo sapiens | |
1.5.1.3 | 0.0028 | - |
5-[(R/S)-2-(2'-methoxyphenyl)pentyl]furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.0033 | - |
5-[(R/S)-2-(2'-methoxyphenyl)hexyl]furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Mus musculus | |
1.5.1.3 | 0.0043 | - |
5-[(Z/E)-2-(2'-methoxyphenyl)hex-1-en-1-yl]furo[2,3-d]-pyrimidine-2,4-diamine | pH 7.4, 37°C | Homo sapiens | |
1.5.1.3 | 0.0046 | - |
5-[(R/S)-2-(2'-methoxyphenyl)-3-methylpentyl]furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Homo sapiens | |
1.5.1.3 | 0.0053 | - |
5-[(R/S)-2-(2'-methoxyphenyl)-4-methylpentyl]furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Homo sapiens | |
1.5.1.3 | 0.011 | - |
5-[(Z/E)-2-(2'-methoxyphenyl)-4-methylpent-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Homo sapiens | |
1.5.1.3 | 0.012 | - |
5-[(R/S)-2-(2'-methoxyphenyl)hexyl]furo[2,3-d]pyrimidine-2,4-diamine | pH 7.4, 37°C | Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.5.1.3 | 0.0019 | - |
pH 7.4, 37°C | Homo sapiens | (E)-5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0032 | - |
pH 7.4, 37°C | Mus musculus | 5-[(R/S)-2-(2'-methoxyphenyl)-3-methylbutyl]furo[2,3-d]-pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0037 | - |
pH 7.4, 37°C | Mus musculus | 5-[(R/S)-2-cyclopropyl-2-(2'-methoxyphenyl)ethyl]furo-[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0039 | - |
pH 7.4, 37°C | Mus musculus | (E)-5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0041 | - |
pH 7.4, 37°C | Mus musculus | 5-[(Z/E)-2-(2'-methoxyphenyl)-3-methylbut-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0042 | - |
pH 7.4, 37°C | Mus musculus | 5-[(Z/E)-2-(2'-methoxyphenyl)-3-methylpent-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0046 | - |
pH 7.4, 37°C | Mus musculus | 5-[(Z/E)-2-cyclopropyl-2-(2'-methoxyphenyl)vinyl]furo-[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.005 | - |
pH 7.4, 37°C | Homo sapiens | 5-[(R/S)-2-cyclopropyl-2-(2'-methoxyphenyl)ethyl]furo-[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0051 | - |
pH 7.4, 37°C | Homo sapiens | 5-[(R/S)-2-(2'-methoxyphenyl)-3-methylbutyl]furo[2,3-d]-pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0064 | - |
pH 7.4, 37°C | Homo sapiens | 5-[(Z/E)-2-(2'-methoxyphenyl)-3-methylbut-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0079 | - |
pH 7.4, 37°C | Mus musculus | 5-[(Z/E)-2-(2'-methoxyphenyl)pent-1-en-1-yl]furo[2,3-d]-pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0086 | - |
pH 7.4, 37°C | Homo sapiens | 5-[(Z/E)-2-(2'-methoxyphenyl)-3-methylpent-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0102 | - |
pH 7.4, 37°C | Homo sapiens | 5-[(Z/E)-2-cyclopropyl-2-(2'-methoxyphenyl)vinyl]furo-[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0122 | - |
pH 7.4, 37°C | Homo sapiens | 5-[(Z/E)-2-(2'-methoxyphenyl)pent-1-en-1-yl]furo[2,3-d]-pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0145 | - |
pH 7.4, 37°C | Mus musculus | (Z)-5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0164 | - |
pH 7.4, 37°C | Homo sapiens | (Z)-5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0259 | - |
pH 7.4, 37°C | Homo sapiens | 5-[(R/S)-2-(2'-methoxyphenyl)pentyl]furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0312 | - |
pH 7.4, 37°C | Mus musculus | 5-[(Z/E)-2-(2'-methoxyphenyl)hex-1-en-1-yl]furo[2,3-d]-pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0333 | - |
pH 7.4, 37°C | Homo sapiens | 5-[(Z/E)-2-(2'-methoxyphenyl)hex-1-en-1-yl]furo[2,3-d]-pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0354 | - |
pH 7.4, 37°C | Mus musculus | 5-[(R/S)-2-(2'-methoxyphenyl)-4-methylpentyl]furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0421 | - |
pH 7.4, 37°C | Homo sapiens | 5-[(R/S)-2-(2'-methoxyphenyl)-3-methylpentyl]furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0445 | - |
pH 7.4, 37°C | Mus musculus | 5-[(R/S)-2-(2'-methoxyphenyl)-3-methylpentyl]furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0519 | - |
pH 7.4, 37°C | Mus musculus | 5-[(Z/E)-2-(2'-methoxyphenyl)-4-methylpent-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0627 | - |
pH 7.4, 37°C | Homo sapiens | 5-[(R/S)-2-(2'-methoxyphenyl)-4-methylpentyl]furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0865 | - |
pH 7.4, 37°C | Homo sapiens | 5-[(Z/E)-2-(2'-methoxyphenyl)-4-methylpent-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.0939 | - |
pH 7.4, 37°C | Homo sapiens | 5-[(R/S)-2-(2'-methoxyphenyl)hexyl]furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.162 | - |
pH 7.4, 37°C | Mus musculus | 5-[(R/S)-2-(2'-methoxyphenyl)pentyl]furo[2,3-d]pyrimidine-2,4-diamine | |
1.5.1.3 | 0.187 | - |
pH 7.4, 37°C | Mus musculus | 5-[(R/S)-2-(2'-methoxyphenyl)hexyl]furo[2,3-d]pyrimidine-2,4-diamine |