EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.11.1.23 | [(2S)-1,1-difluoro-2-hydroxypropyl]phosphonic acid | tight binding inhibitor | Streptomyces wedmorensis |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.11.1.23 | Iron | mononuclear non-heme iron-dependent enzyme | Streptomyces wedmorensis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.11.1.23 | (S)-2-hydroxypropylphosphonic acid + 2 NADH + O2 | Streptomyces wedmorensis | - |
cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+ | i.e. fosfomycin | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.11.1.23 | Streptomyces wedmorensis | Q56185 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.11.1.23 | (S)-2-hydroxypropylphosphonic acid + 2 NADH + O2 | - |
Streptomyces wedmorensis | cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+ | i.e. fosfomycin | ? | |
1.11.1.23 | additional information | the enzyme also forms 2-oxopropylphosphonic acid from (R)-2-hydroxypropylphosphonic acid. HPP epoxidase is not selective with regard to substrate recognition, but can stereospecifically convert each enantiomer into a unique product with similar efficiency | Streptomyces wedmorensis | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.11.1.23 | HPP epoxidase | - |
Streptomyces wedmorensis |