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Literature summary extracted from

  • Klempan, T.; Rujescu, D.; Mérette, C.; Himmelman, C.; Sequeira, A.; Canetti, L.; Fiori, L.; Schneider, B.; Bureau, A.; Turecki, G.
    Profiling brain expression of the spermidine/spermine N1-acetyltransferase 1 (SAT1) gene in suicide (2009), Am. J. Med. Genet. B Neuropsychiatr. Genet., 150, 934-943.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.57 SAT1, microarray expression analysis in brains of control individuals and depressed individuals who have died by suicide, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.57 acetyl-CoA + spermidine Homo sapiens
-
 CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermine Homo sapiens
-
 CoA + N1-acetylspermine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.57 Homo sapiens
-
 French-Canadian population
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.57 brain cortex
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.57 acetyl-CoA + spermidine
-
 Homo sapiens CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermine
-
 Homo sapiens CoA + N1-acetylspermine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.57 SAT1
-
 Homo sapiens
2.3.1.57 spermidine/spermine N1-acetyltransferase 1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.57 acetyl-CoA
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.57 malfunction altered expression of SAT1 in the polyamine stress response, across multiple brain regions between control individuals and depressed individuals who have died by suicide, overview Homo sapiens
2.3.1.57 physiological function SAT1 is the rate-limiting enzyme involved in catabolism of the polyamines spermidine and spermine Homo sapiens