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Literature summary extracted from

  • Song, J.; Jeong, W.; Wang, N.; Lee, H.; Sim, C.J.; Oh, K.; Shin, J.
    Scalarane Sesterterpenes from the Sponge Smenospongia sp (2008), J. Nat. Prod., 71, 1866-1871.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.1 (1S,4bS,10aR,12aS)-10a-[(acetyloxy)methyl]-1-formyl-4b,7,7,12a-tetramethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-2-carboxylic acid scarlarane sesterterpene, isolated from Smenospongia sp. Candida albicans
4.1.3.1 (4S,5bR,11aS,13aS,13bR)-4-hydroxy-5b,8,8,11a,13a-pentamethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate scarlarane sesterterpene, isolated from Smenospongia sp. Candida albicans
4.1.3.1 (4S,5bS,11aR,13aS,13bR)-11a-formyl-4-hydroxy-5b,8,8,13a-tetramethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate scarlarane sesterterpene, isolated from Smenospongia sp. Candida albicans
4.1.3.1 (4S,5bS,11aR,13aS,13bR)-11a-[(acetyloxy)methyl]-5b,8,8,13a-tetramethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1,4-diyl diacetate scarlarane sesterterpene, isolated from Smenospongia sp. Candida albicans
4.1.3.1 (5bS,11aR,13aS,13bR)-11a-(hydroxymethyl)-5b,8,8,13a-tetramethyl-3-oxo-1,3,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate scarlarane sesterterpene, isolated from Smenospongia sp. Candida albicans
4.1.3.1 (5E)-5-[(2R,6E,10E)-13-furan-3-yl-2,6,10-trimethyltrideca-6,10-dien-1-ylidene]-4-hydroxy-3-methylfuran-2(5H)-one linear furanosesterterpene, isolated from Smenospongia sp. Candida albicans
4.1.3.1 (5Z)-5-[(2R,5Z,9Z)-13-furan-3-yl-2,6,10-trimethyltrideca-5,9-dien-1-ylidene]-4-hydroxy-3-methylfuran-2(5H)-one linear furanosesterterpene, isolated from Smenospongia sp. Candida albicans
4.1.3.1 12-deacetoxy-23-acetoxy-19-O-acetylscalarin cytotoxic, isolated from Smenospongia sp. Candida albicans
4.1.3.1 12-deacetoxy-23-acetoxyscalarin cytotoxic, isolated from Smenospongia sp. Candida albicans
4.1.3.1 12-deacetoxy-23-hydroxyheteronemin cytotoxic, isolated from Smenospongia sp. Candida albicans
4.1.3.1 3-nitropropionate
-
 Candida albicans
4.1.3.1 4-hydroxy-9-deoxoidiadione cytotoxic, linear furanosesterterpene, isolated from Smenospongia sp. Candida albicans
4.1.3.1 methyl (1R,4bS,10aR,12aS)-10a-[(acetyloxy)methyl]-1-formyl-4b,7,7,12a-tetramethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-2-carboxylate scarlarane sesterterpene, isolated from Smenospongia sp. Candida albicans
4.1.3.1 methyl (1S,4bS,10aR,12aS)-10a-[(acetyloxy)methyl]-1-formyl-4b,7,7,12a-tetramethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-2-carboxylate scarlarane sesterterpene, isolated from Smenospongia sp. Candida albicans
4.1.3.1 [(5bS,11aR,13aS)-5b,8,8,13a-tetramethyl-5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a-tetradecahydrochryseno[1,2-c]furan-11a(4H)-yl]methanol scarlarane sesterterpene, isolated from Smenospongia sp. Candida albicans
4.1.3.1 [(5bS,11aR,13aS)-5b,8,8,13a-tetramethyl-5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a-tetradecahydrochryseno[1,2-c]furan-11a(4H)-yl]methyl acetate scarlarane sesterterpene, isolated from Smenospongia sp. Candida albicans
4.1.3.1 [(5bS,11aR,13aS,13bR)-1-methoxy-5b,8,8,13a-tetramethyl-1,5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a,13b-hexadecahydrochryseno[1,2-c]furan-11a(3H)-yl]methanol scarlarane sesterterpene, isolated from Smenospongia sp. Candida albicans

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.1 Candida albicans
-
-
-

Synonyms

EC Number Synonyms Comment Organism
4.1.3.1 citrate lyase
-
 Candida albicans

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.1.3.1 additional information
-
 0.006 mg/ml Candida albicans 3-nitropropionate
4.1.3.1 additional information
-
 0.027 mg/ml Candida albicans (5E)-5-[(2R,6E,10E)-13-furan-3-yl-2,6,10-trimethyltrideca-6,10-dien-1-ylidene]-4-hydroxy-3-methylfuran-2(5H)-one
4.1.3.1 additional information
-
 0.0312 mg/ml Candida albicans (5Z)-5-[(2R,5Z,9Z)-13-furan-3-yl-2,6,10-trimethyltrideca-5,9-dien-1-ylidene]-4-hydroxy-3-methylfuran-2(5H)-one
4.1.3.1 additional information
-
 0.042 mg/ml Candida albicans [(5bS,11aR,13aS,13bR)-1-methoxy-5b,8,8,13a-tetramethyl-1,5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a,13b-hexadecahydrochryseno[1,2-c]furan-11a(3H)-yl]methanol
4.1.3.1 additional information
-
 0.0457 mg/ml Candida albicans [(5bS,11aR,13aS)-5b,8,8,13a-tetramethyl-5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a-tetradecahydrochryseno[1,2-c]furan-11a(4H)-yl]methanol
4.1.3.1 additional information
-
 0.055 mg/ml Candida albicans methyl (1R,4bS,10aR,12aS)-10a-[(acetyloxy)methyl]-1-formyl-4b,7,7,12a-tetramethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-2-carboxylate
4.1.3.1 additional information
-
 0.0672 mg/ml Candida albicans 12-deacetoxy-23-acetoxyscalarin
4.1.3.1 additional information
-
 > 0.1 mg/ml Candida albicans (4S,5bR,11aS,13aS,13bR)-4-hydroxy-5b,8,8,11a,13a-pentamethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
4.1.3.1 additional information
-
 > 0.1 mg/ml Candida albicans (4S,5bS,11aR,13aS,13bR)-11a-formyl-4-hydroxy-5b,8,8,13a-tetramethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
4.1.3.1 additional information
-
 > 0.1 mg/ml Candida albicans (4S,5bS,11aR,13aS,13bR)-11a-[(acetyloxy)methyl]-5b,8,8,13a-tetramethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1,4-diyl diacetate
4.1.3.1 additional information
-
 > 0.1 mg/ml Candida albicans (5bS,11aR,13aS,13bR)-11a-(hydroxymethyl)-5b,8,8,13a-tetramethyl-3-oxo-1,3,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
4.1.3.1 additional information
-
 > 0.1 mg/ml Candida albicans 12-deacetoxy-23-acetoxy-19-O-acetylscalarin
4.1.3.1 additional information
-
 > 0.1 mg/ml Candida albicans 12-deacetoxy-23-hydroxyheteronemin
4.1.3.1 additional information
-
 > 0.1 mg/ml Candida albicans methyl (1S,4bS,10aR,12aS)-10a-[(acetyloxy)methyl]-1-formyl-4b,7,7,12a-tetramethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-2-carboxylate
4.1.3.1 additional information
-
 > 0.1 mg/ml Candida albicans [(5bS,11aR,13aS)-5b,8,8,13a-tetramethyl-5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a-tetradecahydrochryseno[1,2-c]furan-11a(4H)-yl]methyl acetate
4.1.3.1 additional information
-
 > 0.1 mg/ml Candida albicans 4-hydroxy-9-deoxoidiadione