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Literature summary extracted from

  • Choi, C.H.; Hyun, S.H.; Kim, J.; Lee, Y.C.; Seol, S.Y.; Cho, D.T.; Lee, J.C.
    Nuclear translocation and DNAse I-like enzymatic activity of Acinetobacter baumannii outer membrane protein A (2008), FEMS Microbiol. Lett., 288, 62-67.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.21.1 into the pET28a expression vector and overexpressed in Escherichia coli BL21 (DE3). His-tagged OmpA expressed in HEp-2 cells Acinetobacter baumannii

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.21.1 additional information the intracellular recombinant OmpA is degraded into several forms of subfragments in the cytosol of the host and two subfragments of recombinant OmpA are translocated into the nuclei Acinetobacter baumannii
-
-
3.1.21.1 outer membrane
-
 Acinetobacter baumannii 19867
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.21.1 Ca2+ exhibits divalent cation-dependent endonuclease activity Acinetobacter baumannii
3.1.21.1 Mg2+ exhibits divalent cation-dependent endonuclease activity Acinetobacter baumannii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.21.1 additional information Acinetobacter baumannii OmpA is a potential virulence factor involved in the induction of host cell death. Acinetobacter baumannii can secrete OmpA during colonization and infection. The pathogenic strategy is that OmpA translocates into the nuclei of host cells and degrades chromosomal DNA by DNAse I-like enzymatic activity ?
-
 ?
3.1.21.1 additional information Acinetobacter baumannii ATCC 19606T OmpA is a potential virulence factor involved in the induction of host cell death. Acinetobacter baumannii can secrete OmpA during colonization and infection. The pathogenic strategy is that OmpA translocates into the nuclei of host cells and degrades chromosomal DNA by DNAse I-like enzymatic activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.21.1 Acinetobacter baumannii
-
 strain ATCC19606T
-
3.1.21.1 Acinetobacter baumannii ATCC 19606T
-
 strain ATCC19606T
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.21.1 additional information OmpA is a potential virulence factor involved in the induction of host cell death. Acinetobacter baumannii can secrete OmpA during colonization and infection. The pathogenic strategy is that OmpA translocates into the nuclei of host cells and degrades chromosomal DNA by DNAse I-like enzymatic activity Acinetobacter baumannii ?
-
 ?
3.1.21.1 additional information OmpA is a potential virulence factor involved in the induction of host cell death. Acinetobacter baumannii can secrete OmpA during colonization and infection. The pathogenic strategy is that OmpA translocates into the nuclei of host cells and degrades chromosomal DNA by DNAse I-like enzymatic activity Acinetobacter baumannii ATCC 19606T ?
-
 ?
3.1.21.1 Xenopus laevis DNA + H2O degrades chromosomal DNA with the characteristic DNA ladders and induces apoptosis of Xenopus embryos Acinetobacter baumannii 5'-phosphooligonucleotides + ?
-
 ?
3.1.21.1 Xenopus laevis DNA + H2O degrades chromosomal DNA with the characteristic DNA ladders and induces apoptosis of Xenopus embryos Acinetobacter baumannii ATCC 19606T 5'-phosphooligonucleotides + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.21.1 OmpA
-
 Acinetobacter baumannii
3.1.21.1 outer membrane protein A
-
 Acinetobacter baumannii