Literature summary extracted from
Wang, Z.; Chernyshev, A.; Koehn, E.M.; Manuel, T.D.; Lesley, S.A.; Kohen, A.
Oxidase activity of a flavin-dependent thymidylate synthase (2009), FEBS J., 276, 2801-2810.
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
2.1.1.148 |
tetrahydrofolate |
competitively inhibits the oxidase activity of the enzyme, which indicates that tetrahydrofolate and O2 compete for the same reduced and dUMP-activated enzymatic complex |
Thermotoga maritima |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.1.1.148 |
Thermotoga maritima |
Q9WYT0 |
enzyme additionally shows oxidase activity |
- |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
2.1.1.148 |
additional information |
flavin-dependent thymidylate synthase can function as an oxidase, which catalyzes the reduction of O2 to H2O2, using reduced NADPH or other reducing agents and a sequential kinetic mechanism of substrate binding. Tetrahydrofolate competitively inhibits the oxidase activity, which indicates that tetrahydrofolate and O2 compete for the same reduced and dUMP-activated enzymatic complex |
Thermotoga maritima |
? |
- |
? |
|