EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.5.3.18 | adiponectin | - |
Homo sapiens | |
3.5.3.18 | all-trans-retinoic acid | 1.9fold increase in DDAH-2 mRNA and protein expression | Mus musculus | |
3.5.3.18 | aminoguanidine | - |
Rattus norvegicus | |
3.5.3.18 | aspirin | - |
Rattus norvegicus | |
3.5.3.18 | EDTA | - |
Rattus norvegicus | |
3.5.3.18 | epigallocatechin gallate | - |
Homo sapiens | |
3.5.3.18 | fenofibrate | - |
Homo sapiens | |
3.5.3.18 | Insulin | - |
Homo sapiens | |
3.5.3.18 | interleukin-1beta | - |
Rattus norvegicus | |
3.5.3.18 | interleukin-1beta | 2fold increase in DDAH-1 protein expression | Rattus norvegicus | |
3.5.3.18 | losartan | - |
Homo sapiens | |
3.5.3.18 | nebivolol | 2fold increase in DDAH-2 mRNA and protein expression | Homo sapiens | |
3.5.3.18 | oestradiol | 60-70% increase in DDAH-2 mRNA and protein expression | Homo sapiens | |
3.5.3.18 | pioglitazone | 2-3fold increase of DDAH-2 mRNA and protein levels | Rattus norvegicus | |
3.5.3.18 | pravastatin | - |
Rattus norvegicus | |
3.5.3.18 | probucol | - |
Homo sapiens | |
3.5.3.18 | taurin | - |
Bos taurus | |
3.5.3.18 | taurin | - |
Rattus norvegicus | |
3.5.3.18 | taurin | - |
Homo sapiens | |
3.5.3.18 | taurine | - |
Oryctolagus cuniculus | |
3.5.3.18 | taurine | - |
Mus musculus | |
3.5.3.18 | telmisartan | - |
Bos taurus | |
3.5.3.18 | telmisartan | - |
Oryctolagus cuniculus | |
3.5.3.18 | telmisartan | - |
Rattus norvegicus | |
3.5.3.18 | telmisartan | - |
Mus musculus | |
3.5.3.18 | telmisartan | - |
Homo sapiens | |
3.5.3.18 | vitamin E | - |
Bos taurus | |
3.5.3.18 | vitamin E | - |
Oryctolagus cuniculus | |
3.5.3.18 | vitamin E | - |
Rattus norvegicus | |
3.5.3.18 | vitamin E | - |
Mus musculus | |
3.5.3.18 | vitamin E | - |
Homo sapiens | |
3.5.3.18 | xanthone | - |
Bos taurus | |
3.5.3.18 | xanthone | - |
Oryctolagus cuniculus | |
3.5.3.18 | xanthone | - |
Rattus norvegicus | |
3.5.3.18 | xanthone | - |
Mus musculus | |
3.5.3.18 | xanthone | - |
Homo sapiens |
EC Number | Application | Comment | Organism |
---|---|---|---|
3.5.3.18 | medicine | influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis | Bos taurus |
3.5.3.18 | medicine | influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis | Oryctolagus cuniculus |
3.5.3.18 | medicine | influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis | Rattus norvegicus |
3.5.3.18 | medicine | influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis | Mus musculus |
3.5.3.18 | medicine | influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.3.18 | 2-(N,N-dimethylamino)diazenolate-2-oxide | 1 mM, 50% inhibition of DDAH-1 | Homo sapiens | |
3.5.3.18 | 2-(N,N-dimethylamino)diazenolate-2-oxide | 1 mM, 50% inhibition of DDAH-1; 1 mM, 50% inhibition of DDAH-1 | Mus musculus | |
3.5.3.18 | 2-(N,N-dimethylamino)diazenolate-2-oxide | 1 mM, 50% inhibition of DDAH-1 | Rattus norvegicus | |
3.5.3.18 | 4-hydroxy-2-nonenal | 50 microM, 50% relative activity | Homo sapiens | |
3.5.3.18 | angiotensin II | 1 microM, about 55% relative activity; 1 microM, about 55% relative activity | Homo sapiens | |
3.5.3.18 | cytokine induced nitric-oxide synthesis | - |
Homo sapiens | |
3.5.3.18 | erythropoetin | 200 units/ml, about 75% relative activity; 200 units/ml, about 75% relative activity | Homo sapiens | |
3.5.3.18 | glucose | - |
Homo sapiens | |
3.5.3.18 | glucose | 25.5 mmol/l; 25.5 mmol/l | Mus musculus | |
3.5.3.18 | glucose | 25.5 mmol/l; 25.5 mmol/l | Rattus norvegicus | |
3.5.3.18 | glycosylated bovine serum albumin | - |
Rattus norvegicus | |
3.5.3.18 | homocysteine | - |
Homo sapiens | |
3.5.3.18 | hydrogen peroxide | 100 microM, 50% relative activity | Homo sapiens | |
3.5.3.18 | lipopolysaccharide | 1 microg/ml, 24 h, about 55% relative activity; 1 microg/ml, about 55% relative activity | Homo sapiens | |
3.5.3.18 | low-density-lipoprotein | 100 microg/ml | Homo sapiens | |
3.5.3.18 | lysophosphatidylcholine | 10 microg/ml, about 35% relative activity | Homo sapiens | |
3.5.3.18 | Mercuric chloride | - |
Rattus norvegicus | |
3.5.3.18 | N-(2-methoxyethyl)-L-arginine | complete inhibition at 100 microM; complete inhibition at 100 microM | Rattus norvegicus | |
3.5.3.18 | N-(2-methoxyethyl)arginine | - |
Mus musculus | |
3.5.3.18 | N-(2-methoxyethyl)arginine methyl esther | - |
Mus musculus | |
3.5.3.18 | N-nitro-L-arginine methylester | 1 mM, 1 h, 47.1% relative activity; 1mM, 1 h, 47.1% relative activity | Bos taurus | |
3.5.3.18 | N-nitro-L-arginine methylester | 1mM, 1 h, 47.1% relative activity | Homo sapiens | |
3.5.3.18 | N-nitro-L-arginine methylester | - |
Mus musculus | |
3.5.3.18 | N-nitro-L-arginine methylester | 1 mM, 1 h, 47.1% relative activity | Oryctolagus cuniculus | |
3.5.3.18 | N-nitro-L-arginine methylester | - |
Rattus norvegicus | |
3.5.3.18 | Nicotine | 50% decrease in DDAH-2 mRNA | Homo sapiens | |
3.5.3.18 | nitric oxide | increased NO production nitrosates DDAH | Homo sapiens | |
3.5.3.18 | nitroglycerine | 10 microM, 16 h, about 55% relative activity; 10 microM, about 55% relative activity | Homo sapiens | |
3.5.3.18 | peroxynitrite | - |
Homo sapiens | |
3.5.3.18 | S-2-amino-4-[N-(2-methoxyethyl)guanidino]butanoic acid benzyl ester | - |
Rattus norvegicus | |
3.5.3.18 | TNF-alpha | 250 U/ml, 63% relative activity | Homo sapiens | |
3.5.3.18 | Zn2+ | 20 microM, 40% relative activity; 20 microM, 40% relative activity | Bos taurus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.3.18 | 0.18 | - |
dimethyl-L-arginine | - |
Bos taurus | |
3.5.3.18 | 0.18 | - |
dimethyl-L-arginine | - |
Oryctolagus cuniculus | |
3.5.3.18 | 0.18 | - |
dimethyl-L-arginine | - |
Rattus norvegicus | |
3.5.3.18 | 0.18 | - |
dimethyl-L-arginine | - |
Mus musculus | |
3.5.3.18 | 0.18 | - |
dimethyl-L-arginine | - |
Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.3.18 | Bos taurus | - |
- |
- |
3.5.3.18 | Bos taurus | Q3SX44 | - |
- |
3.5.3.18 | Homo sapiens | O94760 | - |
- |
3.5.3.18 | Homo sapiens | O95865 | - |
- |
3.5.3.18 | Mus musculus | Q99LD8 | - |
- |
3.5.3.18 | Mus musculus | Q9CWS0 | - |
- |
3.5.3.18 | Oryctolagus cuniculus | - |
- |
- |
3.5.3.18 | Rattus norvegicus | O08557 | - |
- |
3.5.3.18 | Rattus norvegicus | Q6MG60 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.3.18 | aortic endothelial cell | - |
Rattus norvegicus | - |
3.5.3.18 | brain | - |
Bos taurus | - |
3.5.3.18 | ECV304 cell | - |
Homo sapiens | - |
3.5.3.18 | endothelial cell | sEnd-1 cells | Mus musculus | - |
3.5.3.18 | heart | - |
Oryctolagus cuniculus | - |
3.5.3.18 | heart | - |
Rattus norvegicus | - |
3.5.3.18 | heart | - |
Mus musculus | - |
3.5.3.18 | heart | - |
Homo sapiens | - |
3.5.3.18 | heart | - |
Bos taurus | - |
3.5.3.18 | HUVEC cell | - |
Homo sapiens | - |
3.5.3.18 | kidney | - |
Bos taurus | - |
3.5.3.18 | kidney | - |
Oryctolagus cuniculus | - |
3.5.3.18 | kidney | - |
Rattus norvegicus | - |
3.5.3.18 | kidney | - |
Mus musculus | - |
3.5.3.18 | kidney | - |
Homo sapiens | - |
3.5.3.18 | liver | - |
Bos taurus | - |
3.5.3.18 | liver | - |
Oryctolagus cuniculus | - |
3.5.3.18 | liver | - |
Mus musculus | - |
3.5.3.18 | liver | - |
Rattus norvegicus | - |
3.5.3.18 | liver | - |
Homo sapiens | - |
3.5.3.18 | placenta | - |
Oryctolagus cuniculus | - |
3.5.3.18 | placenta | - |
Rattus norvegicus | - |
3.5.3.18 | placenta | - |
Mus musculus | - |
3.5.3.18 | placenta | - |
Homo sapiens | - |
3.5.3.18 | placenta | - |
Bos taurus | - |
3.5.3.18 | pulmonary artery endothelial cell | - |
Mus musculus | - |
3.5.3.18 | smooth muscle | - |
Rattus norvegicus | - |
3.5.3.18 | umbilical vein endothelial cell | - |
Homo sapiens | - |
3.5.3.18 | vascular endothelium | - |
Oryctolagus cuniculus | - |
3.5.3.18 | vascular endothelium | - |
Rattus norvegicus | - |
3.5.3.18 | vascular endothelium | - |
Mus musculus | - |
3.5.3.18 | vascular endothelium | - |
Homo sapiens | - |
3.5.3.18 | vascular endothelium | - |
Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.3.18 | dimethyl-L-arginine + H2O | - |
Bos taurus | L-citrulline + dimethylamine | - |
? | |
3.5.3.18 | dimethyl-L-arginine + H2O | - |
Oryctolagus cuniculus | L-citrulline + dimethylamine | - |
? | |
3.5.3.18 | dimethyl-L-arginine + H2O | - |
Rattus norvegicus | L-citrulline + dimethylamine | - |
? | |
3.5.3.18 | dimethyl-L-arginine + H2O | - |
Mus musculus | L-citrulline + dimethylamine | - |
? | |
3.5.3.18 | dimethyl-L-arginine + H2O | - |
Homo sapiens | L-citrulline + dimethylamine | - |
? | |
3.5.3.18 | Ngamma-monomethyl-L-arginine + H2O | - |
Bos taurus | L-citrulline + methylamine | - |
? | |
3.5.3.18 | Ngamma-monomethyl-L-arginine + H2O | - |
Oryctolagus cuniculus | L-citrulline + methylamine | - |
? | |
3.5.3.18 | Ngamma-monomethyl-L-arginine + H2O | - |
Rattus norvegicus | L-citrulline + methylamine | - |
? | |
3.5.3.18 | Ngamma-monomethyl-L-arginine + H2O | - |
Mus musculus | L-citrulline + methylamine | - |
? | |
3.5.3.18 | Ngamma-monomethyl-L-arginine + H2O | - |
Homo sapiens | L-citrulline + methylamine | - |
? | |
3.5.3.18 | S-methyl-L-thiocitrulline + H2O | - |
Bos taurus | L-citrulline + methanethiol | - |
? | |
3.5.3.18 | S-methyl-L-thiocitrulline + H2O | - |
Oryctolagus cuniculus | L-citrulline + methanethiol | - |
? | |
3.5.3.18 | S-methyl-L-thiocitrulline + H2O | - |
Rattus norvegicus | L-citrulline + methanethiol | - |
? | |
3.5.3.18 | S-methyl-L-thiocitrulline + H2O | - |
Mus musculus | L-citrulline + methanethiol | - |
? | |
3.5.3.18 | S-methyl-L-thiocitrulline + H2O | - |
Homo sapiens | L-citrulline + methanethiol | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.3.18 | DDAH-1 | - |
Bos taurus |
3.5.3.18 | DDAH-1 | - |
Oryctolagus cuniculus |
3.5.3.18 | DDAH-1 | - |
Mus musculus |
3.5.3.18 | DDAH-1 | - |
Rattus norvegicus |
3.5.3.18 | DDAH-1 | - |
Homo sapiens |
3.5.3.18 | DDAH-2 | - |
Oryctolagus cuniculus |
3.5.3.18 | DDAH-2 | - |
Rattus norvegicus |
3.5.3.18 | DDAH-2 | - |
Mus musculus |
3.5.3.18 | DDAH-2 | - |
Homo sapiens |
3.5.3.18 | DDAH-2 | - |
Bos taurus |
3.5.3.18 | dimethylarginine dimethylaminohydrolase | - |
Bos taurus |
3.5.3.18 | dimethylarginine dimethylaminohydrolase | - |
Oryctolagus cuniculus |
3.5.3.18 | dimethylarginine dimethylaminohydrolase | - |
Rattus norvegicus |
3.5.3.18 | dimethylarginine dimethylaminohydrolase | - |
Mus musculus |
3.5.3.18 | dimethylarginine dimethylaminohydrolase | - |
Homo sapiens |