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Literature summary extracted from

  • Kremer, A.; Li, S.M.
    Tryptophan aminopeptidase activity of several indole prenyltransferases from Aspergillus fumigatus (2008), Chem. Biol., 15, 729-738.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.11.17 ATP 7-DMATS, FgaPT1, CdpNPT, and FtmPT1 show 151.6%, 145%, 243.6%, and 149.4% relative activity at 5 mM ATP, respectively Aspergillus fumigatus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.11.17
-
 Aspergillus fumigatus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.17 Ca2+ CdpNPT shows 69.2% relative activity at 5 mM Ca2+ Aspergillus fumigatus
3.4.11.17 Co2+ 7-DMATS, FgaPT1, and CdpNPT show 10.2%, 32.3%, and 46.9% relative activity at 5 mM Co2+, respectively Aspergillus fumigatus
3.4.11.17 EDTA CdpNPT and FtmPT1 are completely inhibited by 5 mM EDTA, 7-DMATS and FgaPT1 show 11.6% and 43.1% relative activity at 5 mM EDTA Aspergillus fumigatus
3.4.11.17 Fe2+ CdpNPT and FtmPT1 show 34.2% and 42.8% relative activity at 5 mM Fe2+, 7-DMATS and FgaPT1 are completely inhibited by 5 mM Fe2+ Aspergillus fumigatus
3.4.11.17 K+ FtmPT1 shows 86.5% relative activity at 5 mM K+ Aspergillus fumigatus
3.4.11.17 Mn2+ 7-DMATS shows 84.0% relative activity at 5 mM Mn2+, FgaPT1 shows 69.7% relative activity at 5 mM Mn2+ Aspergillus fumigatus
3.4.11.17 Zn2+ 7-DMATS, FgaPT1, CdpNPT, and FtmPT1 are completely inhibited by 5 mM Zn2+ Aspergillus fumigatus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.17 Ca2+ FgaPT1 shows 144.2% relative activity at 5 mM Ca2+, FtmPT1 shows 144.1% relative activity at 5 mM Ca2+ Aspergillus fumigatus
3.4.11.17 Co2+ FtmPT1 shows 130.4% relative activity at 5 mM Co2+ Aspergillus fumigatus
3.4.11.17 K+ FgaPT1 shows 117.9% relative activity at 5 mM Co2+ Aspergillus fumigatus
3.4.11.17 Mg2+ FgaPT1 shows 137.9% relative activity at 5 mM Mg2+, FtmPT1 shows 155.2% relative activity at 5 mM Mg2+ Aspergillus fumigatus
3.4.11.17 Mn2+ CdpNPT shows 591.2% relative activity at 5 mM Mn2+, FtmPT1 shows 421.6% relative activity at 5 mM Mn2+ Aspergillus fumigatus
3.4.11.17 additional information 7-DMATS is not activated by 5 mM Ca2+, K+, or Mg2+. CdpNPT is not activated by 5 mM Mg2+ or K+. 7-DMATS, FgaPT1, CdpNPT, and FtmPT1 are not influenced by Na+ Aspergillus fumigatus

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.17 Aspergillus fumigatus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.17
-
 Aspergillus fumigatus

Synonyms

EC Number Synonyms Comment Organism
3.4.11.17 7-DMATS the indole prenyltransferase functions also as tryptophan aminopeptidases and accepts linear dipeptides as best substrates Aspergillus fumigatus
3.4.11.17 CdpNPT the indole prenyltransferase functions also as tryptophan aminopeptidases and accepts linear dipeptides as best substrates Aspergillus fumigatus
3.4.11.17 FgaPT1 the indole prenyltransferase functions also as tryptophan aminopeptidases and accepts linear dipeptides as best substrates Aspergillus fumigatus
3.4.11.17 FtmPT1 the indole prenyltransferase functions also as tryptophan aminopeptidases and accepts linear dipeptides as best substrates Aspergillus fumigatus