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Literature summary extracted from

  • Yi, W.; Cao, R.; Wen, H.; Yan, Q.; Zhou, B.; Wan, Y.; Ma, L.; Song, H.
    Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 6490-6493.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 4-formylphenyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside
-
 Agaricus bisporus
1.14.18.1 4-formylphenyl 2,3,4-tri-O-acetyl-beta-D-allopyranoside
-
 Agaricus bisporus
1.14.18.1 4-formylphenyl 2,3,4-tri-O-benzyl-beta-D-ribopyranoside
-
 Agaricus bisporus
1.14.18.1 4-formylphenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D-glucopyranoside
-
 Agaricus bisporus
1.14.18.1 4-formylphenyl 2,3-O-(1-methylethylidene)-beta-D-allopyranoside
-
 Agaricus bisporus
1.14.18.1 4-formylphenyl 4,6-O-(phenylmethylidene)-beta-D-gulopyranoside
-
 Agaricus bisporus
1.14.18.1 4-formylphenyl 6-O-(dimethoxyphosphoryl)-beta-D-allopyranoside
-
 Agaricus bisporus
1.14.18.1 4-formylphenyl 6-O-trityl-beta-D-allopyranoside
-
 Agaricus bisporus
1.14.18.1 4-formylphenyl beta-D-allopyranoside
-
 Agaricus bisporus
1.14.18.1 4-formylphenyl beta-D-glucopyranoside
-
 Agaricus bisporus
1.14.18.1 4-formylphenyl beta-D-ribopyranoside
-
 Agaricus bisporus
1.14.18.1 4-hydroxybenzaldehyde
-
 Agaricus bisporus
1.14.18.1 4-methoxycinnamic acid
-
 Agaricus bisporus
1.14.18.1 arbutin
-
 Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-tyrosine + O2
-
 Agaricus bisporus L-DOPA + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
 Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.052
-
-
 Agaricus bisporus 4-formylphenyl 4,6-O-(phenylmethylidene)-beta-D-gulopyranoside
1.14.18.1 0.28
-
-
 Agaricus bisporus 4-formylphenyl beta-D-ribopyranoside
1.14.18.1 0.41
-
-
 Agaricus bisporus 4-methoxycinnamic acid
1.14.18.1 0.43
-
-
 Agaricus bisporus 4-formylphenyl 6-O-(dimethoxyphosphoryl)-beta-D-allopyranoside
1.14.18.1 0.62
-
-
 Agaricus bisporus 4-formylphenyl 2,3-O-(1-methylethylidene)-beta-D-allopyranoside
1.14.18.1 0.94
-
-
 Agaricus bisporus 4-formylphenyl beta-D-glucopyranoside
1.14.18.1 1.12
-
-
 Agaricus bisporus 4-hydroxybenzaldehyde
1.14.18.1 2.54
-
-
 Agaricus bisporus 4-formylphenyl beta-D-allopyranoside
1.14.18.1 3
-
-
 Agaricus bisporus 4-formylphenyl 6-O-trityl-beta-D-allopyranoside
1.14.18.1 3
-
-
 Agaricus bisporus 4-formylphenyl 2,3,4-tri-O-acetyl-beta-D-allopyranoside
1.14.18.1 3
-
-
 Agaricus bisporus 4-formylphenyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside
1.14.18.1 3
-
-
 Agaricus bisporus 4-formylphenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D-glucopyranoside
1.14.18.1 3
-
-
 Agaricus bisporus 4-formylphenyl 2,3,4-tri-O-benzyl-beta-D-ribopyranoside
1.14.18.1 8.4
-
-
 Agaricus bisporus arbutin