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Literature summary extracted from

  • Wang, J.; Nes, W.D.
    Cyclobranol: a substrate for C25-methyl sterol side chains and potent mechanism-based inactivator of plant sterol methyltransferase (2008), Bioorg. Med. Chem. Lett., 18, 3878-3881.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.142 24-methyl-9,19-cyclolanost-24-en-3-ol i.e. cyclobranol, competitive Glycine max
2.1.1.142 cyclobranol competitive-type inhibitor Glycine max

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.142 0.037
-
 24-methyl-9,19-cyclolanost-24-en-3-ol
-
 Glycine max
2.1.1.142 0.087
-
 cyclobranol
-
 Glycine max

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.142 43000
-
 SDS-PAGE Glycine max

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.142 Glycine max
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.142 cycloartenol + S-adenosyl-L-methionine
-
 Glycine max 24(28)-methylene cycloartanol + S-adenosyl-L-homocysteine
-
 ?
2.1.1.142 cyclobranol + S-adenosyl-L-methionine
-
 Glycine max 9beta-25-methylidene-9,19-cyclolanost-1-ene-1,3-diol + S-adenosyl-L-homocysteine
-
 ?
2.1.1.142 S-adenosyl-L-methionine + 24-methyl-9,19-cyclolanost-24-en-3-ol i.e. cyclobranol Glycine max S-adenosyl-L-homocysteine + 25-methyl-24-methylidene-9,19-cyclolanostan-3-ol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.142 SMT1
-
 Glycine max
2.1.1.142 sterol C24-methyltransferase
-
 Glycine max

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.1.1.142 0.0001
-
 cyclobranol
-
 Glycine max

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.142 S-adenosyl-L-methionine
-
 Glycine max

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.142 0.025
-
 cyclobranol
-
 Glycine max
2.1.1.142 0.025
-
 24-methyl-9,19-cyclolanost-24-en-3-ol
-
 Glycine max