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Literature summary extracted from
- Redox regulation of transcriptional activity of retinoic acid receptor by thioredoxin glutathione reductase (TGR) (2009), Biochem. Biophys. Res. Commun., 390, 241-246.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.8.1.7 | expressed in NIH-3T3, TM-3, MSC-1, and TM-4 cells | Mus musculus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.7 | Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.7 | GSSG + NADPH + H+ | - |
Mus musculus | GSH + NADP+ | - |
? |  |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.7 | TGR | - |
Mus musculus |
| 1.8.1.7 | thioredoxin glutathione reductase | - |
Mus musculus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.7 | FAD | - |
Mus musculus | |
| 1.8.1.7 | NADPH | - |
Mus musculus | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.8.1.7 | physiological function | thioredoxin glutathione reductase binding to retinoic acid receptor is required for the retinoic acid-dependent retinoic acid receptor association with chromatin, retinoic acid receptor activity damaged by oxidative stress is restored by thioredoxin glutathione reductase | Mus musculus |
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Release 2023.1 (January 2023)
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