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Literature summary extracted from

  • Burke, K.T.; Horn, P.S.; Tso, P.; Heubi, J.E.; Woollett, L.A.
    Hepatic bile acid metabolism in the neonatal hamster: expansion of the bile acid pool parallels increased Cyp7a1 expression levels (2009), Am. J. Physiol. Gastrointest. Liver Physiol., 297, G144-G151.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.23 microsome
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 Mesocricetus auratus
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-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.23 Mesocricetus auratus
-
-
-
1.14.14.29 Mesocricetus auratus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.23 liver
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 Mesocricetus auratus
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1.14.14.29 additional information CYP7B1 is elevated by 1.5 days postpartum compared with other ages, levels decrease in the midneonatal period and then increase by 20.5 days postpartum Mesocricetus auratus
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Synonyms

EC Number Synonyms Comment Organism
1.14.14.23 cholesterol 7alpha-hydroxylase
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 Mesocricetus auratus
1.14.14.23 CYP7A1
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 Mesocricetus auratus
1.14.14.29 CYP7B1
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 Mesocricetus auratus
1.14.14.29 oxysterol 7alpha-hydroxylase
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 Mesocricetus auratus

Expression

EC Number Organism Comment Expression
1.14.14.23 Mesocricetus auratus postpartum: increase in mRNA and protein levels of cholesterol 7alpha-hydroxylase up
1.14.14.23 Mesocricetus auratus significant increase in Cyp7a1 levels in neonatal hamsters is due to mechanisms independent of the FXR and SHP pathway and cortisol. Precocious expression of Cyp7a1 can not be induced in neonatal hamsters with dexamethasone up

General Information

EC Number General Information Comment Organism
1.14.14.29 physiological function key enzyme in bile acid synthesis by the alternative pathway Mesocricetus auratus