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Literature summary extracted from

  • Coelho, P.A.; Queiroz-Machado, J.; Carmo, A.M.; Moutinho-Pereira, S.; Maiato, H.; Sunkel, C.E.
    Dual role of topoisomerase II in centromere resolution and Aurora B activity (2008), PLoS Biol., 6, e207.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.6.2.2 additional information TOPO II is required to promote Aurora B kinase activity Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.2.2 additional information Drosophila melanogaster topoisomerase II ensures proper sister chromatid separation through a direct role in centromere resolution and prevents incorrect microtubule-kinetochore attachments by allowing proper activation of Aurora B kinase, TOPO II activity is required to establish amphitelic kinetochore attachment, TOPO II is required for centromere separation independently of the cohesin complex ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.2.2 S2 cell
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.2 additional information topoisomerase II ensures proper sister chromatid separation through a direct role in centromere resolution and prevents incorrect microtubule-kinetochore attachments by allowing proper activation of Aurora B kinase, TOPO II activity is required to establish amphitelic kinetochore attachment, TOPO II is required for centromere separation independently of the cohesin complex Drosophila melanogaster ?
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 ?
5.6.2.2 supercoiled DNA + ATP + H2O
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 Drosophila melanogaster catenated DNA networks + ADP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.2.2 topo II
-
 Drosophila melanogaster
5.6.2.2 Topoisomerase II
-
 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
5.6.2.2 ATP
-
 Drosophila melanogaster